生体内退質材料(Biodegradable material)による膀胱補填再建について

概要

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Since the urinary bladder has large regenerative ability, supplementation for the purpose of enlargement is required only until a sufficient regeneration of the bladder tissue is accomplished. This study was aiming to develop a biodegradable material for use in reconstruction of the bladder to serve a temporary function until normal regrowth of the host's tissue is completed. The biodegradable material can serve as a base over which the new bladder can regenerate. At the conclusion of the regrowth of the new tissue, the temporary material could be consumed by the body tissue and therefore not have to be removed. Bovine pericardium treated with 70% acetic anhydride was found being digested and dissolved in 4 weeks when implanted subcutaneously in dogs. Based upon this, supplementation of the bladder using this material was performed on 5 dogs. One dog showed urinary leakage and was sacrificed after one week. In 3 dogs examined for 4, 6 and 48 weeks after implantation, respectedly, the implanted material had been dissloved. In one animal autopsied after ten and a half months, a small remnant of the material still remained. Postoperative observation of the animals, excretory pyelocystograms and cystometry confirmed that the material applied was useful for experimental urinary bladder supplementation.
社団法人日本泌尿器科学会の論文