N-Butyl-N-(4-Hydroxybutyl)-Nitrosamineによるラット膀胱腫瘍の血液線溶系

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There are many reports on the relationship among malignant tumors, blood clotting and fibrinolytic enzyme system. The present report describes the fibrinolytic enzyme system in plasma of rats with experimental urinary bladder tumor. The plasma was separated into three fractions with lysine-sepharose affinity chromatography. The materials were Wistar-Imamichi strain male rats which had been administered a dose of 0.02 mg/head/day of N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) from 8 weeks old to 16 weeks old and then sacrified at 28 weeks old. Fraction-I did not contain either plasmin (PL) or plasminogen activator (PLg-act). Though the normal rat plasma sometimes has a slight antiplasmic action, the plasma of rats which had been administered BBN had a marked antiplasmic action. However, the action did not correspond with bladder tumor and hyperplasia. The rat plasma had an antiurokinase activity irrespective of BBN-administration. Sometimes fraction-II had also PLg-act irrespective of BBN-administration. On the rats which had been administered BBN, the activity of PLg-act in the bladder tumor-group and in the hyperplasia-group had an increasing tendency which was more marked than that in the unchanged group. Fraction-III revealed mainly the PL-activity. Normal rats had no activated PL, but the animals administered BBN revealed PL-activity. The PL-activity in the unchanged group had a more marked increasing tendency that in the bladder tumor group and hyperplasia group.
社団法人日本泌尿器科学会の論文
1975-11-20

N-Butyl-N-(4-Hydroxybutyl)-Nitrosamineによるラット膀胱腫瘍の血液線溶系

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