血液透析療法中の慢性腎不全患者の血漿β-Thromboglobulin

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Abnormal platelet function of patients with chronic renal failure (CRF) has been documented. We have measured β-thromboglobulin (β-T.G.), a platelet specific protein in 33 patients with CRF undergoing hemodialysis using a β-T.G.RIA kit, and have investigated whether the β-T.G. can be an indicator of the clinical condition of these patients. The patients were 23 males and 10 females, with the mean age of 42.7 years (range 23 to 73 years). The mean term of hemodialysis was 23.8 months (range 2 to 65 months) and the mean serum creatinine (S-crea) was 13.14 mg/dl (range 5.7 to 18.8 mg/dl). The mean plasma β-T.G. value of the patients was 122.52±50.12 ng/ml (range 56.3 to 250 ng/ml, n=49), and was significantly higher than that of 11 normal control subjects which was 29.03±14.98 ng/ml (range 7.3 to 62.1 ng/ml, n=24) (p<0.001). The mean platelet-count of the patient was 188,900±51,600 (range 86,000 to 268,000, n=32), which was lower than that of control subjects with platelet count of 252,000±43,200 (range 154,000 to 306,000, n=13). The β-T.G. value of the patients showed a correlating tendency with the S-crea, value, but it was not significant. The β-T.G. value did not correlate with the urine volume, platelet count, red blood cell count, white blood cell count, hemoglobin value, hematocrit, sodium, potassium and calcium in the blood.
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