尿路結石症の研究(第18報) : 高度なる腎石灰沈着症を伴える骨軟化症の1例

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Recently, the relationship between renal insufficiency and bone changes has attracted the urologist's interest, because there is a striking tendency to stone formation and calcification of renal parenchyma in some osseous diseases. A man, 45 year old, was admitted to our hospital, complaining of spontaneous fractures. X-ray examinations revealed fractures of ribs, clavicle, scapula, pelvis and four extremities and bilateral renal calcifications of high grade. Biochemical analyses of the blood and urine demonstrated tubular insufficiency to excrete acid urine, which has led to acidosis and hypercalcuria. Diagnosis is osteomalacia with nephrocalcinosis due to primary renal acidosis. Osteomalacia is a distinct clinical entity readily differentiated from other generalized osseous diseases by physicochemical examinations.
社団法人日本泌尿器科学会の論文