膀胱腫瘍とβ-Glucuronidase

概要

論文の詳細を見る
β-glucuronidase activities of serum, urine and exudates from the bladder, which were collected from the patients with genitourinary diseases, especially bladder tumors, were studied. The results were as follows: l) β-glucuronidase activity in urine indicated a high level in the morning and low in the afternoon. 2) There were not so remarkable changes between urine volume andβ-glucuronidase activity in one day. 3) An adequate incubation time for determination ofβ-glucuronidase activity was 24 hours. No bacterial affects onβ-glucuronidase could be found. 4) In normal, they have shown almost the same levels ofβ-glucuronidase activity in separate urine from the kidneys and bladder. The other hand, the patients with bladder tumors, especially cancers, their β-glucuronidase activity showed abnormal high levels in bladder urine and exudates from the bladder after urinary diversion. But after extirpation of bladder tumors, it indicated a normal β-glucuronidase activity in bladder urine. 5) A normal level of β-glucuronidase activity in urine collected from the kidneys and bladder was below 1.30 μg/ml/hr. 6) A high urinary β-glucuronidase activity of bladder tumors was inhibited by treatments with SLA and other various anti-cancer drugs. 7) We found two obvious peaks, during study of β-glucuronidase isozymes pattern. We consider that there are two isozymes in β-glucuronidase.
社団法人日本泌尿器科学会の論文