男性半陰陽の下垂体性腺系内分泌機能に関する研究

概要

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Pituitary-gonadal endocrine function was studied by measuring serum LH, FSH and testosterone (T) levels under various conditions using radioimmunoassay methods in 18 patients with various types of male hermaphroditism. Among them, 11 patients were classified as group A1 (;male hermaphroditism with no breast development and rudimentary or no mullerian structures), 3 patients as group A2 (;male hermaphroditism with well formed mullerian structures) and 2 patients as group B2 (;male hermaphroditism with breast development and ambiguous external genitalia) according to the classification modified from that proposed by Jones. In the other 2 patients, it was not determined whether they belonged to group A1 or group B2 because of their prepubertal age. In addition, 4 patients with true hermaphroditism and 3 padents with gonadal dysgenesis were studied for comparison. The pubertal and postpubertal patients with male hermaphroditism excluding those of group B2 showed strikingly elevated levels of both serum LH and FSH. The levels of serum LH and FSH were further elevated by LH-RH administration. Serum T levels in them were widely ranged from subnormal to normal adult male levels, and hCG stimulation test revealed a poor Leydig cell reserve capacity in some cases.
社団法人日本泌尿器科学会の論文