膀胱癌の治療法に関する研究 : 第2篇 : 進行性膀胱癌に対する制癌剤の内腸骨動脈内注入療法

概要

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Infusion of MMC into the internal iliac artery was carried out for 13 cases with progressive inoperable bladder cancer. The following results were obtained. 1) Cystoscopy at the time of discharge showed disappearance of the tumor in four cases of them and reduction in three cases. 2) After intra venous injection of one shot of MMC to the patient with bladder cancer, the maximum concentration in blood showed within five minutes and then decreased rapidly. The MMC concentration in the median cubital vein after infusion into the internal iliac arteries was lower than the concentration after administration by intravenous drip infusion. MMC excreted into urine corresponded to about 5 to 10% of the dose given. 3) Pathological examinations of the tumor tissue after this therapy revealed edema in interstitium, hyperplasia of connective tissue and round cell infiltration, in a dition to vacuolation and swelling of protoplasm, pyknosis, nuclear decay and disappearance of cancer cells. Futher, no atypical cells were found by the examination of urinary exfoliated cells.
社団法人日本泌尿器科学会の論文