睾丸間質機能の検討 : 第2報性微発来不全について

概要

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The effects of synthetic luteinizing hormone-releasing hormone (LH-RH) on plasma pituitary gonadotropins (LH and FSH) and human chorionic gonadotropin (HCG) on plasma testosterone (T.) were studied in fourteen boys with delayed puberty including one Prader-Willi syndrome. T. was measured at one hour intervals in 180 minutes after HCG administration (intramuscular 10,000 units) on day 0 and on day 4 before and six hours after HCG administration (intramuscular 3,000 units) and on days 5, 6, 7, and 8 six hours after HCG administration (daily, intramuscular 3,000 units). Short term responses were poor except one case, but good responses were found before HCG administration on day 4 and increases were steady after daily HCG administration in the same eleven cases. In other three cases including Prader-Willi syndrome responses were poor to HCG administrations. LH to LH-RH (intraveneously 100μg) was meaningful in cases with good responses of T. to HCG and not meaningful in cases with poor responses of T. to HCG except one case. For FSH to LH-RH, no correlation was found between T. to HCG.
社団法人日本泌尿器科学会の論文