6-Hydroxydopamineの排尿機構に及ぼす影響 : 第二篇各種神経因性膀胱患者への投与

概要

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The Effects of 6-Hydroxydopamine (6-OHDA) was studied on 18 patients, of whom 12 patients with upper motor neuron lesion and six patients with lower motor neuron lesion, suffering from neurogenic bladder with high residual urine. Local injection of 6-OHDA ( 1 mg/kg) was performed cystoscopically at 3, 6, 9 and 12 o'clock positions around proximal urethra throughout the perineum. Cystogram, Cystometrograms and Phenoxybenzamine test (improvement in voiding pattern or reduction of maximum urethral pressure using urethral pressure profile studies) were carried out in each patient. The following results were obtained : 1) Improvement of voiding pattern was obtained in 10 patients. 2) The achievement of bladder emptying was mainly due to increases of the bladder pressure and was partially related with alpha-adrenolytic effect of chemical sympathectomy by local administration of 6-OHDA, in view of cystograms cystometrograms and phenoxybenzamine test. 3) In 13 patients, blood pressure rose temporarily at the time of injection but, it was restored shortly after treatment. Vesico-ureteral reflux was observed in four patients after local administration of 6-OHDA. Three of them recovered after two months without special therapy. Massive hematuria was observed in two cases. No other significant complications were noted.
社団法人日本泌尿器科学会の論文
1978-07-15