局所麻酔剤の作用に及ぼす Hyaluronidase の影響(第一報)

概要

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In the practice of surface anesthesia by the local anesthetics in the field of dental and oral surgery, an instant and deep penetration of the anesthetics is most desirable. But in some specific cases long anesthesia is not necessary. In this respect auther has studied the influence of hyaluronidase on the action of several local anesthetics using the corneal-reflex of rabbits. The local anesthetics were xylocaine, carbocaine, dibucaine and tetracaine. The results obtained were summarized as follows. When hyaluronidase was added to the local anesthetics, the corneal-reflex disapeared readily just like control but the duration of anesthesia shortened with compared to the controls. This shortening of anesthesia is surely owing to the action of Hyaluronidase which promotes absorption of local anesthetics. However, the appearance of anesthesia was not earlier than that of control. This is due to the concentration of anesthetics was too hight. In the experiment of tetracaine in relatively low concentration the anesthesia appeared faster than that of the control.
九州歯科学会の論文
1965-03-31