亜鉛欠乏ラットの有郭乳頭および味上皮の組織化学的研究

概要

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Weanling male rats were fed a zinc-deficient diet, 1.3ppm zinc and controls the same diet supplemented by 40ppm zinc for four weeks. Zinc-deficient rats showed growth retardation, loss of hairs and skin changes similar in appearance to acrodermatitis enteropathica. Hyperparakeratotic alterations of the tongue epithelium were observed in zinc-deficient rats. When observed by scanning electron microscopy, the circumvallate papilla of the zinc-deficient rat was buried by hyperparakeratinized cells and was often difficult to find in the dorsal lingual surface. No discernible change on the activity of ATPase, ALPase and adenylate cyclase in the circumvallate papilla was observed between controls and zinc-deficient rats. It seemed that one of the causes for hypogeusia in zinc-deficient rat might relate to blockage of gustatory substances from the papillary region by hyperparakeratosis. Other plausible pathogenesis was also discussed.
九州歯科学会の論文
1990-06-25