ハムスター頬嚢の発癌過程における基底板の変化に関する電子顕微鏡的研究

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概要

• 論文の詳細を見る

• Basal lamina alterations during experimental carcinogenesis in hamster cheek pouch were investigated electron microscopically and the results obtained were as follows ; 1. Basal lamina alterations, including thinned out, discontinuity, separation of basal lamina from basal plasma membrane and reduplication were observed from the time of epithelial hyperplasia with proliferation of connective tissues of lamina propria. 2. The thinned-out and discontinuity of basal lamina were observed so more frequently and intensely as epithelial hyperplasia progressed to dysplasia that basal lamina loss was dominant observations in dysplasia stage. 3. Reduplication of basal lamina was also observed more frequently and intensely as epithelial hyperplasia progressed but was rare observations in epithelial dysplasia stage. 4. Inflammatory reaction which were indicated ultrastructurally by less compactness and disruption of the subjacent connective tissues of lamina propria was observed getting more intense as epithelial hyperplasia stage progressd to dysplasia stage. 5. In carcinoma stage, basal lamina alterations, including thinned-out, discontinuity, loss of basal lamina and reduplication were observed as continuous linear one. Dominant observations were discontinuity and loss of basal lamina and these were commonly found around the invasive tumor cell nests. Well developed reduplication of basal lamina was observed especially around the tumor cell nests of epithelial pearl formation. 6. Various forms of cytoplasmic processes of basal cell i.e., pseudopodia, bleb, etc. could be observed at the places corresponding to the region of the discontinuity and the loss of basal lamina. These cytoplasmic processes were ubiquitous findings independent of stages of carcinogenesis. 7. The results of the observation support the idea that the production of basal lamina and its functions are basically physiologic characteristic unrelated to carcinoma. 8. The basal lamina loss observed around invasive tumor cell nests indicated that the production of type IV collagenase by the tumor cells and laminin, physiologic constituents of basal lamina, may still be factors in tumor invasion. Further studies about basal lamina will elucidate the tumor cell invasion.

• 九州歯科学会の論文
• 1986-10-25

著者

• 鹿毛 俊孝

  松本歯科大学口腔外科学第1講座

• 鹿毛 俊孝

  松本歯科大学口腔外科学教室第1講座

関連論文

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