Haloxazolam(ソメリン[○!R])の術前夜睡眠薬としての臨床的検討

概要

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For the purpose of improving the sleep on preoperative night, 10mg of haloxazolam was administered to the patients listed for general anesthesia. A total of 59 patients were investigated by dividing them into two groups, a drug administered group (H-group) and a placebo done control group (P-group). The results obtained were as follows : 1. The general subjective symptom and sleep symptoms of patients were improved in the H-group. The sleep symptoms were checked on falling asleep, halfway awake, sleeping duration and awakening feeling. Among them, only the frequency of halfway awake was decreased in the H-group with a statistical significance (P<0.05). The improvement of other symptoms were not significant. 2. The memories of having dreams in the H-group were rather clear than in the P-group, and it was not found significant. Therefore it was postulated that the dose amont (10mg) of haloxazolam as hypnotic was not enough to cause improvement of sleep on preoperative night. Nemerous reports have certified that this dose of the drug is sufficient to cure insomnia in internal medicine or pshychiatry. In clinical anesthesia, however, more than this dose could be administered, with careful consideration on sex, age, body weight, and the sleeping or anxiety during hospitalizaton.
九州歯科学会の論文
1985-06-25