実験的笑気吸入の雑種成犬副腎髄質カテコールアミン遊離に及ぼす影響

概要

論文の詳細を見る
The effects of nitrous oxide (30, 50, 70%) inhalation on the catecholamine release from adrenal medulla were investigated. Mongrel dogs were used as the experimental subjects and were intubated and ventilated mechanically. Blood samples were taken out directly from the adrenal vein. The epinephrine (EP) and norepinephrine (NE) contents were measured with high performance liquid chromatography-electrochemical detector (HPLC-ECD). The results were as follows : 1. The EP and NE releases into the adrenal vein were decreased significantly when dogs inhaled under 30% or 50% nitrous oxide. 2. The EP and NE releases under 30% nitrous oxide inhalation were decreased in all the subjects, and those under 50% nitrous oxide inhalation were increased in 3 of the 14 subjects. 3. No signigicant changes in the EP and NE releases were observed under 70% nitrous oxide inhalation. These results show that both 30% and 50% nitrous oxide decrease the catecholamine release from adrenal medulla into blood, while 70% nitrous oxide doesn't. The changing point of the gas concentration to effect on the catecholamine release can be postulated to exist between 50 and 70%.
九州歯科学会の論文
1986-02-25