Perturbation of Rat Alveolar Bone Remodeling under Bisphosphonate (HEBP) Regimen : Osteoid-mediated ankylosis and its convalescence accompanying the periodontium reconstruction

スポンサーリンク

概要

• 論文の詳細を見る

• The present study was undertaken to investigate the effects of systemic HEBP (1-hydroxyethylidene-1, 1-bisphosphonate) administration on the alveolar bone structure at the intraradicular region of rat lower molars. Male Wistar rats (about 100 g b.w.) were divided into three groups: (a) animals kept with drinking water containing 1% HEBP throughout the housing periods covering 4 days through 8 weeks; (b) animals given the same HEBP-containing water during the initial 4 weeks, thereafter being kept with HEBP-free drinking water for various periods (4-28 days); and (c) animals kept free from HEBP during the corresponding periods as the control group. The tooth specimens were examined by histometric analysis in conjunction with H.E., van Gieson, and TRAP stainings; or by microradiography. The results obtained evidenced that: 1) systemic administration of 1% HEBP stimulated the outgrowth of osteoid due to hindrance of mineralization onto the deposited bone matrix and osteoclastic resorption activity, giving rise to obliteration of the periodontal space (development of focal ankylosis); and 2) after cessation of the HEBP administration, TRAP-positive osteoclasts penetrated into the ankylosed areas, leading to reconstruction of the periodontal structure within the following 3 to 4 weeks. It is pertinent that the use of HEBP to rat provides an experimental model for pathogenesis of the osteoid-mediated ankylosis and its reversible recovery.

• 特定非営利活動法人日本臨床口腔病理学会の論文
• 1999-06-20

著者

• Sato Kaori

  Department of Pathology, The Nippon Dental University, School of Dentistry at Tokyo

• Aoba Takaaki

  Department of Pathology, The Nippon Dental University, School of Dentistry at Tokyo

• Sato K

  Nippon Dental University Department Of Pathology

• Sato Kaori

  日本歯科大学 病理学

• YAGISHITA Hisao

  Department of Pathology, The Nippon Dental University

• Sato Kaori

  Department Of Molecular Biology Tokyo Metropolitan Institute Of Medical Science

• Komatsu Hideyuki

  Department of Pathology, The Nippon Dental University

• Komatsu Hideyuki

  Department Of Pathology The Nippon Dental University School Of Dentistry At Tokyo

• Komatsu Hideyuki

  Department Of Bioscience And Bioinfomatics Faculty Of Computer Science And Systems Engineering Kyusy

• Aoba T

  Department Of Pathology School Of Life Dentistry At Tokyo Nippon Dental University

• Aoba Takaaki

  Department Of Pathology Faculty Of Dentistry Nippon Dentistry University

• Sato K

  Nippon Dental Univ. School Of Dentistry At Tokyo Tokyo Jpn

• Yagishita H

  Department Of Pathology Nippon Dental University School Of Life Dentistry At Tokyo

• Sato Kaori

  Department Of Bacteriology Shinshu University School Of Medicine

• Yagishita Hisao

  Department of Pathology, Nippon Dental University School of Life Dentistry at Tokyo

• SATO Kaori

  Department of Anatomy, School of Medicine, Sapporo Medical University

関連論文

• Thermodynamic and Kinetic Interpretation of Enamel Mineralization Octacalcium Phosphate (OCP) as an Inevitable Intermediate Phase
• Small-Angle X-Ray Scattering and Computer-Aided Molecular Modeling Studies of 20 kDa Fragment of Porcine Amelogenin: Does Amelogenin Adopt an Elongated Bundle Structure?^1
• Pedicled Pericardial Flap for Pulmonary Artery in Adult Dogs
• Clinico-Pathological Studies on the Current State and Features of Carious Lesions in the Permanent Teeth of the Japanese Population
• Degradation of Fodrin by m-Calpain in Fibroblasts Adhering to Fibrillar Collagen I Gel
• Spike Formation by Fibroblasts Adhering to Fibrillar Collagen I Gel
• Spike formation by fibroblasts adhering to fibrillar collagen I gel
• CELL SPIKE FORMATION AND m-CALPAIN ACTIVATION IN SKIN FIBROBLASTS ADHERING TO FIBRILLAR COLLAGEN I.
• The Reconstituted Type I Collagen Fibrils from Skins of Variously Aged Bovines Exert Different Effects on the Morphology and Integrin α2β1 Expression of Fibroblasts in Culture
• Fluoride and apatite formation in vivo and in vitro
• Effects of Long-term Fluoride Administration on the Composition and Solubility of Rat Cortical Bone
• Sexual dimorphism of porcine amelogenins : male-specific amelogenins have strong adsorption properties onto apatite crystals
• Mechanistic Understanding of the Stage-specific Accumulation of Magnesium Ions in Developing Enamel:Simulation of Coupling Events at the Crystal/Solution Interface in an in vitro Precipitation Model
• Spatio-temporal Expression Patterns of Gelatinolytic Activity in Mouse Secondary Palates
• Kinetic Consideration of Ca Transport and Associated Crystal Precipitation in an in vitro Precipitation Model Using Dialysis Membranes : Fluoride-dependent Regulation of Ca Concentration in Liquid Environment
• Aggregation of 20 kDa Porcine Amelogenin in Solution : FTJR and AFM Analysis of the Accompanying Protein-conformational and Morphological Changes
• Functional Significance of Pyrophosphate in Discrete Forms in Mineralizing Milieus
• Perturbation of Rat Alveolar Bone Remodeling under Bisphosphonate (HEBP) Regimen : Osteoid-mediated ankylosis and its convalescence accompanying the periodontium reconstruction
• Carbonation of Enamel Apatite Crystals : Lattice Substitutions and Surface Adsorption
• Two Discrete Calcium Environments on the Surface of Enamel and Synthetic Apatites
• Consideration of the functional significance of dicarboxylic amino acids in calcium apatite precipitation
• Tissue Maturation of Fibro-osseous Lesions with Respect to the Inorganic Constituents and Crystallographic Features
• 1P147 ATP,ADP及びPiの有機溶媒に対する溶解性(水・水和/電解質,第48回日本生物物理学会年会)
• Effects of endothel in-1 (ET-1) on craniofacial morphogenesis : Use of Er-1 knockout mice.
• Stoichiometry and Thermodynamic Solubility Properties of Dentin Mineral of Human Permanent and Deciduous Teeth
• Malignant Lymphoma of the Thyroid with Evidence of an Epstein-Barr Viral Infection Concomitant with Thalassemia Minor : Report of a Case
• Soluble Constituents in the Fluid Environment of Pig and Rat Developing Enamel and Their Relevance to the Regulation of Mineralization
• Occurrence and Histopathologic Features of Odontoclastic Resorption on the Internal Dentin Wall after Replantation of Rat Molars
• Aggregation of Partially Unfolded Myosin Subfragment-1 into Spherical Oligomers with Amyloid-Like Dye-Binding Properties
• Patterning of Molar Tooth Roots in Mammals
• Hertwig's Epithelial Cells and Multi-root Development of Molars in Mice
• Solubility Properties of Carbonatoapatites with Discrete Stoichiometric Compositions
• Chronology of temporomandibular joint development and timings of tissue-marker expression in mice.
• Fate of Medial Edge Epithelium in Mouse Palatogenesis in vitro : Apoptosis, Migration, and Epithelial-mesenchymal Transformation
• Assimilated epithelial fusion and mesenchymal confluence of mouse palatogenesis in culture
• 2P044 Visualization of domain structure of bacterial glucosyltranseferase-I by electron cryo-microscopy(29. Protein structure and dynamics (II),Poster Session,Abstract,Meeting Program of EABS & BSJ 2006)
• Molecular Mechanisms Governing Early Myogenesis of Mouse Tongue
• Voyage to the Land of Developmental Enamel Mineralization
• Construction of a Combined Notl/Smal Physical and Genetic Map of Moraxella (Branhamella) catarrhalis Strain ATCC25238
• Three-dimensional visualization and quantification for the growth and invasion of oral squamous cell carcinoma
• Sensitive heme sensor using fluorescent-labeled heme oxygenase-1
• Degradation of Fodrin by m-Calpain in Fibroblasts Adhering to Fibrillar Collagen I Gel
• Microscopic analysis of the iliofemoral and ischiofemoral ligaments in the hip joint : collagen fiber direction and crimp distribution

もっと見る 閉じる

スポンサーリンク