Occurrence and Histopathologic Features of Odontoclastic Resorption on the Internal Dentin Wall after Replantation of Rat Molars
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概要
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The etiology, pathogenesis and prognosis of internal root resorption in human dentition remain to be bertter understood. The present study aimed to gain better insight into the pathways by which multinucleated odontoclasts are recruited and activated on the dentin wall, giving rise to resorption lacunae in the disrupted pulp environment after tooth replantation. The upper first molars were luxated and then repositioned in the original socket. Post-treatment events were monitored over 28 days, and tissue speciments were prepared at time intervals. Histologic examination of the mesial and disto-palatal roots of the replanted first molars verified the occurrence of resorption lacunae accompanying TRAP-positive multinuclear cells on the internal dentin wall around day 7 after tooth replantation. Ninety-nine resorption lacunae were detected for the histologically examined 46 roots. These lacunae were classified into A and B types, which appeared to correspond to surface and inflammatory types of external root resorption, respectively. Key events leading to the establishment of odontoclastic resorption of the pulp-side dentin wall were the replacement of the innate pulp tissue with the ingrowth of granulation tissues and the assembly of a new cell population comprising macrophages and fibroblastic stromal cells. The overall results support the hypothesis that the innate pulp of rat molars possesses in potency inhibitory functions against undesirable resorption activities, but after impairment of the innate pulp environment after tooth replantation, a new paradigm of cell-matrices and cell-cell interactions may act cooperatively to induce clastic activities on the internal predentin/dentin wall.
- 特定非営利活動法人日本臨床口腔病理学会の論文
- 2001-12-25
著者
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KATSUUMI Ichiroh
Department of Endodontics and Operative Dentistry, School of Life Dentistry at Tokyo, Nippon Dental
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Katsuumi Ichiroh
Department Of Endodontics And Operative Dentistry
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Katsuumi Ichiroh
Department Of Pathology And Department Of Endodontics And Operative Dentistry
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Aoba T
Department Of Pathology School Of Life Dentistry At Tokyo Nippon Dental University
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Shimazu Yoshihito
The Nippon Dental University
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Yagishita Hisao
The Nippon Dental University
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Sato Shunichiro
Department of Pathology and Department of Endodontics and Operative Dentistry
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Kondo Chihiro
Department of Pathology and Department of Endodontics and Operative Dentistry
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Aoba Takaaki
The Nippon Dental University
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Yagishita H
Department Of Pathology Nippon Dental University School Of Life Dentistry At Tokyo
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Shimazu Yoshihito
Department Of Pathology Nippon Dental University School Of Life Dentistry At Tokyo
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Kondo Chihiro
Department Of Clinical Oncology Aichi Cancer Center Hospital
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