Spatio-temporal Expression Patterns of Gelatinolytic Activity in Mouse Secondary Palates

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概要

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• The present study utilizing histozymography was undertaken to localize gelatinolytic activities in the epithelium and mesenchyme of embryonic mouse secondary palate. At the stages of vertical position through elevation, the mesenchyme of the palatal shelves exhibited relatively strong gelatinolytic activities, whereas the epithelia covering the palatal shelves did not show distinctive gelatinolytic activities. The location of gelatinolytic activities in the mesenchyme changed markedly after the palatal shelves started reorientation. Modest to strong enzymatic activities were first elicited in the medial edge epithelium (MEE), when the bilateral palatal processes confronted each other prior to their contact. RT-PCR analysis also confirmed the mRNA expression of MMP-2, MMP-9, MT1-MMP, and TIMP-1 in the palatal shelves at the corresponding developmental stages. The results obtained support the view that the spariotemporal regulation of gelatinolytic activities is a key factor to reorganization of the epithelial and mesenchymal components during embryonic palate morphogenesis.

• 特定非営利活動法人日本臨床口腔病理学会の論文
• 2001-06-30

著者

• Sato Kaori

  Department of Pathology, The Nippon Dental University, School of Dentistry at Tokyo

• Aoba Takaaki

  Department of Pathology, The Nippon Dental University, School of Dentistry at Tokyo

• Sato K

  Nippon Dental University Department Of Pathology

• Sato Kaori

  日本歯科大学 病理学

• YAGISHITA Hisao

  Department of Pathology, The Nippon Dental University

• Sato Kaori

  Department Of Molecular Biology Tokyo Metropolitan Institute Of Medical Science

• Taya Yuji

  Department of Pathology, The Nippon Dental University, School of Dentistry at Tokyo

• Soeno Yuuichi

  Department of Pathology, The Nippon Dental University, School of Dentistry at Tokyo

• SHIMAZU Yoshihito

  Department of Pathology, Nippon Dental University School of Dentistry at Tokyo

• Taya Yuji

  Nippon Dental University Department Of Pathology

• Aoba T

  Department Of Pathology School Of Life Dentistry At Tokyo Nippon Dental University

• Aoba Takaaki

  Department Of Pathology Faculty Of Dentistry Nippon Dentistry University

• Soeno Yuuichi

  Department Of Pathology School Of Life Dentistry At Tokyo The Nippon Dental University

• Sato K

  Nippon Dental Univ. School Of Dentistry At Tokyo Tokyo Jpn

• Yagishita H

  Department Of Pathology Nippon Dental University School Of Life Dentistry At Tokyo

• Taya Yuji

  Department Of Pathology School Of Life Dentistry At Tokyo Nippon Dental University

• Shimazu Yoshihito

  Department Of Pathology Nippon Dental University School Of Life Dentistry At Tokyo

• Sato Kaori

  Department Of Bacteriology Shinshu University School Of Medicine

• Yagishita Hisao

  Department of Pathology, Nippon Dental University School of Life Dentistry at Tokyo

• SATO Kaori

  Department of Anatomy, School of Medicine, Sapporo Medical University

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