血清ビリルビン代用物質としてのジタウロビリルビンの化学特性

概要

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The chemical characteristics of ditaurobilirubin, which is a synthesized conjugated bilirubin, have been investigated. The absorption maximum, spectrum and absorption intensity of this substance changed in the presence of methanol, Triton X-100, human albumin or serum protein, and its absorbance at the absorption peak increased by the addition of methanol and protein. Also, these four substances promoted the photochemical reaction of ditaurobilirubin. Its change to other substances by the irradiation of light was several times faster than unconjugated bilirubin, but in this reaction biliverdin almost did not formed. However, even at 4℃ in the dark ditaurobilirubin spontaneously changed to biliverdin for a short term, unlike unconjugated bilirubin. In the diazo coupling reaction, a colored product readily formed, but its stability was low. The absorption maximum of the colored product was close to that formed from the serum direct bilirubin when the reaction was performed in the presence of human albumin, serum protein or Triton X-100.
2000-11-05