炭酸カルシウム投与のウサギのビタミンB_2排泄にたいする影響

概要

論文の詳細を見る
The author observed that by the administration of 200mg CaCO_3 to subjects for five days the urinary excretion of riboflavin increased ca. 2.6 times that of standard diet. In order to ascertain the cause of this findings, the following studies were made. Using homosulfamine as an inhibitor of riboflavin synthesis in intestines, the factor was assayed for 6 subjects for 22 days, dividing 4 periods of time, the 1st, standard diet ; the 2nd, CaCO_3 administration, the 3rd, CaCO_3+homosulfamine added ; and the last, standard diet. (1) Six experimental subjects showed maximum excretion of riboflavin in the urine at the CaCO_3 administration period. Only one subject showed some reduction in the urine output at the CaCO_3+homosulfamine period, but not so low as homosulfamine alone. (2) The concentration of riboflavin in blood increased about all subjects in next order. 2nd period (CaCO_3 administrated)>1st period>3rd period. (3) The fecal excretion of riboflavin could not show any evident results. (4) An attempt for rabbits to inhibit the biosyntnesis of riboflavin in the intestine by the administration of homosulfamine for a period of five days met with success as well as in man.
日本ビタミン学会の論文