抗生物質共存下におけるビタミン類の微生物定量法 : (IV)ペニシリンGおよびクロールテトラサイクリン, テトラサイクリン共存下におけるビタミン類の定量

概要

論文の詳細を見る
A microbiological assay method of pantothenic, folic and nicotinic acid in the urine excreted after penicillin G, chlortetracycline or tetracycline dosage was studied. All of these antibiotics were inhibitory on the growth of lactobacilli at a relatively low concentration, but these antibiotic actions were weakened with autoclaving because these antibiotics were decomposed by this means. Two method were presented for microbiological assay of the above vitamins. In the one of autoclaved samples hitherto used lactobacilli and in the other antibiotic resistant strains were used as test organisms. The latter was more preferable for routine assay because of no need of autoclaved samples. One exception was, however, observed in penicillin resistant strains which could not grow in the synthetic medium for assay of vitamins.
日本ビタミン学会の論文