アスコルビン酸リン酸エステルの化学と応用

概要

論文の詳細を見る
By phosphorylation of 5,6-isopropylidene-L-ascorbic acid, a mixture of some phosphoric acid esters of AsA were obtained, and from this mixture, four esters (AsA-2-phosphate, -3-phosphate, -3-pyrophosphate, bis- AsA-3,3'-phosphate) were isolated. AsA-3-phosphate was most stable among these four esters and the other esters changed to -3-phosphate in aqueous solution. AsA-3-phosphate and its salt were stable in water, especially in neutral or alkaline solution containing boric acid or its salt. AsA-phosphate was hydrolyzed with phosphatase of liver or skin to corresponding AsA and exhibited vitamin C activity. The topical therapy with an ointment containing AsA-phosphate Mg was carried out in the treatment of various pigmented dermatoses for a long time and found to be effective. Accordingly, AsA-phosphate Mg is available for dermatological and cosmetic uses.
日本ビタミン学会の論文
1970-06-25