ビタミンB_1-重金属化合物 : (V)金属中毒時のビタミンB_1の動態(1)2価銅イオンによるビタミンB_1分解の機構とその意義

概要

論文の詳細を見る
A new type of thiamine-copper complex, previously reported, shows a thiamine decomposing power nearly corresponding to equimolar concentration of copper ion. On this basis, an assumptive scheme on the degradation mechanism of thiamine by copper ion is presented. That is to say, in a thiamine solution contaminated with Cu^<2+>, alternative formation and degradation of the thiamine-copper complexes may occur, and this may be the cause of the gradual decomposition of thiamine by Cu^<2+>. Based on the results of spectrophotometrical studies, the practical significance of the thiamine-heavy metal complexes is discussed, e. g., possible mechanisms leading to avitaminosis in metal-poisoning are speculated : viz., the state of thiamine deficiency may be caused by the decomposition of thiamine by copper ion as well as by thiamine fixing in thiol type by the formation of mercaptide complexes with Ag^+, Cu^<2+>, and Hg^<2+>.
日本ビタミン学会の論文
1969-05-25