非経口的に投与された給合型ビタミンB_2の生体内運命について

概要

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1) Healthy persons were administered parenterally with riboflavin, FMN and FAD respectively, and the riboflavin concentration in their blood and urine was examined at appropriate intervals of time. The majority of riboflavin in the blood was present in free form, even if bound riboflavin had been given, and the free riboflavin was excreted in the urine within 2 hours following injection. No recongnizable difference was observed among the three types of riboflavin in this investigation. 2) Free riboflavin, FMN or FAD each was mixed with human or rabbit blood and kept in a dark room for 60 minutes at 37℃ and then the amount both of total and bound riboflavin of each blood was examined. In the case of FMN, 54 per cent of free riboflavin were obtained, and in the case of FAD, 40 per cent. This is similar to the result of the load-test in vivo.
日本ビタミン学会の論文