ビタミンB_2代謝におよぼすハロゲン化炭化水素化合物の影響に関する実験的研究 : (III)中毒マウスに対するビタミンB_2負荷時の臓器内B_2量の変動について

概要

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Mice were intoxicated with the administration of CCl_4 or chlorodiphenyl and then were loaded with free riboflavin, FMN or FAD. They were sacrified 10,30,60 and 120 minutes after riboflavin loading and the riboflavin concentrations in the liver, kidney, heart and intestinal wall were examined. 1) The transportation of riboflavin into normal liver was more remarkable by the loading of esterified riboflavin than by free one. The esterified riboflavin thus introduced was rapidly dephosphorylated and disappeared from the liver. In the intoxicated liver the transportation of riboflavin was less remarkable than in the normal. 2) The transportation of riboflavin into kidney was more marked in the intoxicated animals than in normal. However, the disappearance of riboflavin introduced was more rapid in the intoxicated mice. 3) The increased riboflavin in the intestinal wall of animals was in free form, even if esterified riboflavin had been loaded.
日本ビタミン学会の論文