ビタミンB_2代謝に及ぼすハロゲン化炭化水素化合物の影響に関する実験的研究 : (I)中毒ウサギに対するビタミンB_2負荷時の血中B_2濃度, 尿中排泄B_2量ならびに臓器B_2量の変動について

概要

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Riboflavin was loaded to the rabbits intoxicated with CCl_4,CHCl_3,chlorodiphenyl and chloronaphthalene, as well as to the normal rabbits. The changes of riboflavin concentration in the blood and urine were followed. Riboflavin concentrations in the organs and histological changes of the liver of intoxicated animals were also examined. 1) When free riboflavin, FMN or FAD was loaded to the normal rabbits, the curves of the concentrations of total and esterified riboflavin against time in the blood and urine were similar regardless of the agents used. 2) When riboflavin was loaded to the intoxicated rabbits, the maintenance of high concentrations of riboflavin in the blood was recogniged. The concentration of total riboflavin in the urine of intoxicated animals decreased markedly compared to the control animals. But the increase of esterified riboflavin in the urine was observed only when esterified riboflavin was given. 3) Riboflavin concentration in the liver and kidney of the intoxicated rabbits decreased remarkably, but the decrease in the heart was not remarkable. 4) The histological changes of the liver intoxicated with CCl_4 were the most severe among all of the agents used.
日本ビタミン学会の論文