ビタミンB_2代謝に及ぼすハロゲン化炭化水素化合物の影響に関るす実験的研究 : (II)中毒過程のウサギに対するビタミンB_2負荷時の血中ならびに尿中ビタミンB_2量の変動と病理組織像の関係について

概要

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Rabbits were injected intramuscularly with CCl_4 or chlorodiphenyl dissolved in olive oil twice a week, and free riboflavin or FMN was loaded parenterally during the process of intoxication. 1) The curves of the concentrations of riboflavin against time in blood and urine changed abnormally in proportion to the damage of liver tissue. 2) The remarkable decrease of riboflavin concentrations both in the liver and kidney was observed a week after the administration of the toxic substances, and there was no appreciable difference in the riboflavin concentration in these organs between 1 and 3 weeks. 3) CCl_4 influenced the metabolism of riboflavin more strongly than chlorodiphenyl. But their mode of influence did not differ markedly from each other.
日本ビタミン学会の論文