ビタミンDの代謝実験 : (II)クル病ネズミにビタミンDを負荷したときのビタミンD代謝

概要

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Rats weighing about 40 g raised with rachitogenic diets were given a single dose of 1 mg ergocalciferol. Twenty-four hours after the dose, about 16 per cent was detected, of which 1/3 was in the body and the rest in feces. Eighty-four per cent of the dose had been consumed in 24 hours. Following a single dose of 1 mg ergocalciferol, the vitamin in the liver rose gradually, reaching a maximum level in 12 hours, whereby about 7 per cent of the dose had been recovered. Thereafter it fell gradually. After successive doses, varying in amount in each, of ergocalciferol, the vitamin in the body rose with a rise in the vitamin given. The vitamin in the feces showed no tendency to rise with the duraton of administration. The rise in body weight after giving 50 or 100 μg ergocalciferol was about the same as the control. After giving 500 or 1000 μg, the body weight fell from the fifth day, and the animals in the latter case fell into a serious condition.
日本ビタミン学会の論文