菌體成分に關する研究 (第8報) : Fungisterol の化學構造に就て(其の2)

概要

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1) Fungisterol was isolated in pure state from the mycelia of Penicilleium chrysogenum obtained from submerged culture. The color reactions of this sterol by ROSENHEM's test showed no pecuriaties, but differed in some details from ergosteiol.2) According to the determination by using perbenzoic acid, fungisterol has three double bonds, two of which are conjugated in one ring.3) Fungisteryl bonzoate (m. p. 155/6°), fungisteryl hexabromide(in. p. 99/100°), fungisteryl acetate maleate (m. p. 186°), fungisteryl meleate (m. p. 158°), and fungisteryl digitonide (decomp. 230°), were obtained. The molecular weight of fungisteryl acetate was ascertained as 440 (molecular formula C_<28>H_<44>O) by the elemental analysis and the determination of acetyl number.4) Fungisterol has -C_9H_<17> group as side chain in its structure, the oxidation of which gives methyl isopropyl acetaldehyde as in the case with ergosterol having one double bond between C_<22> and C_<28>.5) The chemical structure of fungisterol is considered to be ergostatriene(? : ?, ? : ?, 22 : 23)-o1-3 (double linkage conjugated in one ring), so that it is an isomer of ergosterol.
社団法人日本生物工学会の論文
1953-04-15