ラット脳のミエリン形成に及ぼすニコチン酸の影響

概要

論文の詳細を見る
The present study was undertaken to determine whether the transfer of cerebroside from the site of synthesis (microsome) to the site of myelin assembly was impaired in rats fed on a nicotinic acid-deficient diet. We measured the radioactivity in cerebroside in subcellular fractions (microsome and myelin) after intracerebral injection of [U-^<14>C]-L-serine in the brain of 22 day old rats which received nicotinic acid or saline and they were fed on the nicotinic acid-deficient diet for 10 days from 12th days after birth. In both the groups which received nicotinic acid or saline, the specific activity of cerebroside in microsome increased sharply 4 h after injection of ^<14>C-serine and then declined during the next 24 h. On the other hand, the specific activity of cerebroside in myelin increased during these periods. This observation indicated that cerebroside synthesized in microsome fraction was transferred to myelin in both the nicotinic acid-deficient rats which received nicotinic acid or saline.
日本ビタミン学会の論文
1985-03-25