シロネズミにおけるメチルコバラミン-^<57>Coの生体内運命, とくにビタミンB_<12>同族体への転換

概要

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CH_3-B_<12> fraction was confirmed in rats fed freely, and after the administration of 4mg of CH_3-B_<12> total cobalamin in liver and kidney apparently increased and the ratio of CH_3-B_<12> fraction in total cobalamin fraction increased at least in liver. Following the parenteral adminstration of 2μg of CH_3-B_<12>-^<57>Co to the male rats, the hepatic and renal uptakes of ^<57>Co and the forms of cobalamins in both organs were measured for two weeks. Three hours after the administration, apporoximately ninety percent of the total activity in both organs was found in both fractions of OH-B_<12> and DBCC, while the CH_3-B_<12> fraction was demonstrated only in ten percent. After that, the radioactivity of OH-B_<12> fraction of liver came down gradually, with DBCC fraction increasing simultaneously. The activity of CH_3-B_<12> fraction also decreased slowly. The urinary excretion of CH_3-B_<12>-^<57>Co was higher than that of OH-B_<12>-^<57>Co. The kidney : liver uptake ratio of CH_3-B_<12>, on the other hand, resembled to DBCC.
日本ビタミン学会の論文
1969-11-25