高ビタミンB_<12>血症にかんする研究 : (I)白血病における高ビタミンB_<12>血症
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概要
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Vitamin B_<12> levels in blood, plasma and leukocytes from 55 leukemia patients were assayed microbiologically. The mean B_<12> levels of blood and plasma before therapy were 5,267,5,966 μμg/ml in chronic granulocytic leukemia (CGL), 2,220,2,240 in acute granulocytic leukemia (AGL), 2,366,1,866 in monocytic leukemia, 1,638,804 in acute lymphocytic leukemia (ALL) and 767,1062 μμg/ml in myelofibrosis. B_<12> contents of cells per 10^8 cells were 1,161 μμg in AGL and 484 in CGL with a 1% level significance. But observation of cell B_<12> levels may not be of much help in differentiating acute leukemias. In CGL and some acute leukemias, elevated plasma concentrations of B_<12> showed gradual lowering of the levels following therapy. No increased B_<12> levels in blood of CGL were found during development of leukocytosis, in accordance with increase in leukocyte count, but, within a week after initiation of antileukemic agent administration, a slight elevation in B_<12> was seen. It was suggested that the increased B_<12> might be caused by B_<12> liberation into plasma due to leukocyte destruction. The high B_<12> levels in acute leukemia before therapy do not appear to be directly related with immature cell contents of blood. No correlations were also found between blood B_<12> levels and hematological or histochemical findings. Consequently, it was suggested that the high B_<12> levels of blood and plasma in CGL may have no direct relations with the pathogenesis of CGL, but appears to be a secondary phenomenon, and furthermore, a possibility that the stagnation of B_<12> in blood may be due to its liberation by the pathological destruction of leukemic leukocytes was discussed.
- 日本ビタミン学会の論文
- 1968-10-25
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