實驗高血壓の病理組織學的研究(第4報) : 特に腎心脈管系について : 第五章 DCA高血壓 : 第六章 考按總活

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概要

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• The author made histopathological study on various types of experimental hypertension, i. e., renal, neurogenic, salt loading or DCA hypertension.Special attention has been paid to the relation between the observed histological lesion and the magnitude of hypertension or the method whereby to produce hypertension, in an effort to disclose the underlying mechanism of experimental hypertension. The results were as follows : 1. Different methods whereby to produce hypertension result in similar histological change which is of essentially the same character with that of hypertension in man.2. With regard to neurogenic hypertension, magnitude of renal lesion was independent upon that of hypertension. Instead, it was rather linearly proportionate to the length of time allowed after the peformance of operation.3. As to renal hypertension, magnitude of renal lesion was not proportionate with that of hypertension. Moreover, pronounced renal lesion occurred in the absence of hypertension.4. Abruptly developing hypertension of severe degree resulting from pressoreceptor denerving or renal hypertension-inducing procedure was found to cause enlargement of glomeruli and exudation into the Bowman's capsular space.5. In salt hypertension induced animals, most pronounced lesion occurred in fully loaded animals. However, no clear relation existed between the magnitude of lesion and that of hypertension. With cessation of salt loading, blood pressure gradually fell off and it appeared that the histological lesion regressed roughly proportionately to the length of cessation. This regression, if it is such, of histological lesion appeared due, not to the fall of blood pressure, but to the cessation of salt loading itself.6. In DCA hypertensive animals there occurred enlargement of convoluted tubule as it was the case with salt hypertension. This change occurred in great severity in those treated in conjugation with salt. With same degree of hypertension, this lesion was pronounced exclusively in unilaterally nephrectomized rats. In DCA hypertension as well as in salt hypertension, therefore, important is the retention of sodium.7. No definite relation existed between the hypertrophy of the heart and hypertension or its duration.8. Generally, the more extensive the injuried area, the more striking the hypertension.It is concluded that the elevation of blood pressure can not be simpley correlated to the lesion in the kidney, heart and blood bessels with classical inference of cause and result, that the two, on the contrary, should rather be treated as a unity. The author approves the theory, which explains the matter clearly, the disturbance in ATP-ATPase system causes elevation of blood pressure, and at the same time, lesion of blood bessels.

• 社団法人日本循環器学会の論文
• 1959-08-20

著者

• 杉島 節郎

  京都大學醫學部内科學第三講座

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• 實驗高血壓の病理組織學的研究(第III報) : 特に腎心脈管系について : 第四章 食鹽高血壓
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