實驗高血壓の病理組織學的研究(第III報) : 特に腎心脈管系について : 第四章 食鹽高血壓

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概要

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• Hypertension was induced in albino rats by subjecting them to prolonged administration, in various ways, of hypertonic saline solution. Main observed histological lesion included : proliferative thickening or necrosis of the renal arterioles, involving tubules and glomeruli. Alteration in tubules was characterized by the diatation of convoluted tubule with swelling of the epithel cells. Since the degree of hypertension induced in albino rats was nearly equal throughout the entire group of animal, and it appears that all the rats were subject to nearly equal amount of influence, it seems appropriate to infer that the observed difference in degree of histological lesion is due to different way of treating the animals So, the author compares the two group with each other, a group of animals in which salt loading was interrupted, and another group of animals in which it was not interrupted. Within the latter group placed under the salt loading without interruption (A, B, F), the author encountered striking difference between two animals of sub-group A with regard to the histological picture despite the fact that the two animals had been treated in the same way and showed the same degree of hypertension. This relation also held for sub-group B. To the contrary, sub-group F showed discrepant degree of hypertension despite equal magnitude of histological lesion. The above fact indicates that the elevated blood pressure can never be the only factor causing the pathological alteration. As to the group under the salt loading with interruption (C. D. E), blood pressure began falling immediately after the cessation of loading salt. At the same time, the observed histological change was generally slight in degree. It was also indicates that the longer the time allowed between the cessation of salt loading and autopsy, the slighter the histological lesion. This seems to suggest that the cessation of salt loading caused the blood pressure to fall and, at the same time, the histological lesion to regress, not that the regression of histological lesion caused the blood pressure to fall.In view of the above fact it appears that the retention of Na (sodium) is most responsible for the developement of histological changes in salt hypertension. This conclusion is in good agreement with Maekawa's theory that the Na retention activates renal ATPase and causes its liberation into the blood stream.

• 社団法人日本循環器学会の論文
• 1959-06-20

著者

• 杉島 節郎

  京都大學醫學部内科學第三講座

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• 實驗高血壓の病理組織學的研究(第III報) : 特に腎心脈管系について : 第四章 食鹽高血壓
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