リケッチア症の心電圖所見 : 特に抗生物質小量長期投與を受けた症例について

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Progress in the antibiotic treatment facilitates management of rickettsiosis. Treatment with tetracycline and its derivatives in the dosis described elsewhere, however, is complicated with relapse frequently. To prevent this relapse avoiding physical and economical inconvenience of the patient, principle of small-amount and long-term antibiotic treatment of rickettsiosis was established by Katsura and his associates. The gradual defervescence during the treatment in this principle might cause irreversible disturbances to the patient treated.The purpose of present report is to know whether irreversible changes in cardiovascular system would occur or not, during the course or treatment in this principle. For this purpose electrocardiographic tracings of thirteen cases on naturally infected tsutsugamushi disease and twenty-four cases of inoculated rickettsiosis, as a pyrotherapy of metasyphilis, are studied.In three of thirteen natural cases of tsutsugamushi disease minor changes in ST-T segment are observed. But the changes in two cases are so slight that they are usually neglected in routine clinical practice. The changes above mentioned are observed in the febril stage.In fourteen of twenty-four inoculated cases, the same changes are observed but they are also very slight in twenty cases. Difference between the frequency of occurrence in natural and inoculated cases is chiefly due to the following conditions. (i) All inoculated cases are suffering from syphilis in various forms. (ii) All of them are elder than natural cases. (iii) Duration of febril stage in inoculated cases is always longer than natural cases because of necessity for pyrotherapy. (iv) The same patients are successively inoculated with the other rickettsiae and included in cases described if his symptoms are not subsided.No significant differences in electrocardiographic findings are observed among the cases inoculated with R. tsutsugamushi (Niigata and or Shichitostrain), R. tamiyai, and R. sennetsu.The tracings after the complete defervescence reveal no persistent changes.
社団法人日本循環器学会の論文
1959-01-20

リケッチア症の心電圖所見 : 特に抗生物質小量長期投與を受けた症例について

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