Therapeutic Strategy for Long QT Syndrome based on Genetic Diagnosis(Morning Lecture 14 (ML14) (A))(Special Program)

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概要

• 論文の詳細を見る
• 社団法人日本循環器学会の論文
• 2004-03-01

著者

• HORIE Minoru

  Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science

• Horie Minoru

  Department Of Cardiovascular And Respiratory Medicine Shiga University Of Medical Science

• Horie Minoru

  Department Of Cardiac Physiology National Cardiovascular Center Research Institute

関連論文

• Comparison of the long-term effects of candesartan and olmesartan on plasma angiotensin II and left ventricular mass index in patients with hypertension
• FRS-031 Additional Gene Modifiers Reduce Effectiveness of β-blockers in the Long QT Type 1 Syndrome(Arrhythmia-Basic : Molecular and Genetic : Basis (A) : FRS4)(Featured Research Session (English))
• ECG Findings in Andersen's Syndrome : Action Potential Simulation Study
• ECG Findings in Andersen's Syndrome : Action Potential Simulation Study
• NRSF Is Involved in Molecular Pathways for Sudden Death Associated with Heart Failure
• Hydroxyzine, a First Generation H_1-Receptor Antagonist, Inhibits Human Ether-a-go-go-Related Gene (HERG) Current and Causes Syncope in a Patient With the HERG Mutation
• PJ-571 Multiple Mechanisms underlie Long QT Syndrome by the Change of Amino Acid R259 in the Intracellular S4-S5 Linker of KCNQ1(PJ096,Arrhythmia, Others (Clinical/Pathophysiology) 4 (A),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The
• PE-106 SCN5A and Lamin A/C Gene Mutations are Highly Prevalent in Patients with Familial Bradyarrhythmic Disorders(PE018,Arrhythmia, Others (Clinical/Pathophysiology) (A),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulat
• Association of Atrial Arrhythmia and Sinus Node Dysfunction in Patients With Catecholaminergic Polymorphic Ventricular Tachycardia
• Whole-Body Periodic Acceleration Enhances Brachial Endothelial Function
• PJ-457 Chronic Effects of Angiotensin II Receptor Blockade on Coronary Fibrinolytic Function in Patients with Coronary Artery Disease(Coronary circulation, basic/clinical-3, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• PJ-453 Effects of Chronic Smoking on Coronary Fibrinolytic Function in Women with Normal Coronary Arteries(Coronary circulation, basic/clinical-2, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• Relationship between Metabolic Syndrome and Trp64Arg Polymorphism of the β3-Adrenergic Receptor Gene in a General Sample : The Shigaraki Study
• The Association between Morning Hypertension and Metabolic Syndrome in Hypertensive Patients
• Impact of Paraoxonase Polymorphism (Q192R) on Endothelial Function in Intact Coronary Circulation
• PJ-772 The Present Condition of the Morning Hypertension Patients after JSH2004(Hypertension, clinical-12 (H) PJ134,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
• PJ-689 Relationship between a Metabolic Syndrome and the Polymorphism of the Beta3 Adrenergic Receptor Gene in a General Sample (S-town study)(Diabetes/Obesity/Metabolic syndrome-13 (H) PJ116,Poster Session (Japanese),The 70th Anniversary Annual Scientifi
• PJ-388 The Impact of Whole-body, Periodic Acceleration on Vascular Endothelial Function and Nitric Oxide Release(Exercise test/Cardiac rehabilitation-3 (IHD) PJ66,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Cir
• PJ-010 Aortic Stiffening Precedes Coronary Endothelial Dysfunction in Type II Diabetes Mellitus(Coronary circulation, basic/clinical-4 (IHD) PJ2,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
• PJ-689 Relationship between a Metabolic Syndrome and the Polymorphism of the Beta3 Adrenergic Receptor Gene in a General Sample (S-town study)(Diabetes/Obesity/Metabolic syndrome-13 (H) PJ116,Poster Session (Japanese),The 70th Anniversary Annual Scientifi
• PJ-388 The Impact of Whole-body, Periodic Acceleration on Vascular Endothelial Function and Nitric Oxide Release(Exercise test/Cardiac rehabilitation-3 (IHD) PJ66,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Cir
• FRS-149 Mutation Site-Specific Differences in Arrhythmic Risk and Sensitivity to Sympathetic Stimulation in Japanese Families with Congenital LQT1 Syndrome(Sudden Cardiac Death (A) : FRS18)(Featured Research Session (English))
• 5 Genotype- and Mutation site-Specific Differences in Arrhythmic Risk and Sensitivity to Sympathetic Stimulation in the Long QT Syndrome(APSC/JCS Joint Symposium (APSC) (H) : Emerging Issue in Cardiology for Asian)(Special Program)
• ECG Findings in Andersen's Syndrome : Action Potential Simulation Study
• Novel Mutation of Plakophilin-2 Associated With Arrhythmogenic Right Ventricular Cardiomyopathy
• A novel SCN5A gain-of-function mutation M1875T associated with familial atrial fibrillation
• PJ-571 Multiple Mechanisms underlie Long QT Syndrome by the Change of Amino Acid R259 in the Intracellular S4-S5 Linker of KCNQ1(PJ096,Arrhythmia, Others (Clinical/Pathophysiology) 4 (A),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The
• PE-106 SCN5A and Lamin A/C Gene Mutations are Highly Prevalent in Patients with Familial Bradyarrhythmic Disorders(PE018,Arrhythmia, Others (Clinical/Pathophysiology) (A),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulat
• Combined Analysis of Polymorphisms in Angiotensinogen and Adducin Genes and Their Effects on Hypertension in a Japanese Sample : The Shigaraki Study
• Change of Medication to Candesartan is Effective for Patients with Early Morning Surge in Blood Pressure (from the ATOM Study) (Hypertension, Clinical 10 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• 1 Molecular Basis for Low Penetrance in the Long QT Syndrome(Meet the Expert 7 (ME7) (A) : Issues on Sudden Cardiac Death)(Special Program)
• Molecular and Genetic Basis for the Treatment of Long QT-Related Lethal Ventricular Arrhythmias
• Verapamil binding sites of K_ channel may reside on the cytosolic end of the TM2 of the pore-forming subunit, Kir6.2
• Why does intracoronary ACh injection induce torsade de pointes in long QT syndrome? : Role of Nitric Oxide
• Therapeutic concentrations of bepridil voltage-dependently block of IK_s reconstituted by KCNQ1/KCNE1
• LQT1, but not LQT2, patients show an exercise-induced increase in transmural dispersion of repolarization (TDR)
• Electrical Remodeling of the Ventricular Myocardium in Myocarditis : Studies of Rat Experimental Autoimmune Myocarditis
• OJ-012 Mutation Analysis for the Human Cardiac Ryanodine Receptor Gene (RyR2) in Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT)(Arrhythmia, diagnosis/pathophysiology/EPS-03, The 71st Annual Scientific Meeting of the Japanese Circulation Soci
• PE-104 Severer Phenotypes of Long QT Syndrome are Associated with Compound Mutations : A Multicenter Study(PE018,Arrhythmia, Others (Clinical/Pathophysiology) (A),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Soci
• FRS-052 Identification and Functional Characterization of a Novel Intronic Splicing Mutation in KCNQ1 Associated with Long QT Syndrome(FRS11,New Insights into Basic Mechanisms of Arrhythmia (A),Featured Research Session (English),The 73rd Annual Scientifi
• 2 Latent Genetic Backgrounds and Molecular Pathogenesis of Drug-induced Long QT Syndrome(Proarrhythmic Risk of Drugs and Their Evaluation,Symposium 7 (SY-07) (I),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• 1 A Novel Genetic Marker for Potential Risk of QT Prolongation and Cardiac Sudden Death : KCNE1-D85N Polymorphism(Biomarkers, Genetic Polymorphism, and Risk Estimation,Symposium 1 (SY-01) (H),The 73rd Annual Scientific Meeting of The Japanese Circulation
• Dynamic Change in ST-Segment and Spontaneous Occurrence of Ventricular Fibrillation in Brugada Syndrome With a Novel Nonsense Mutation in the SCN5A Gene During Long-Term Follow-up
• Mutation Analysis of the Glycerol-3 Phosphate Dehydrogenase-1 Like (GPD1L) Gene in Japanese Patients With Brugada Syndrome
• Mutation Site Dependent Variability of Cardiac Events in Japanese LQT2 Form of Congenital Long-QT Syndrome
• A Novel Mutation Associated With Jervell and Lange-Nielsen Syndrome in a Japanese Family
• PE-251 Mutation analysis of the Glycerol-3 Phosphate Dehydrogenase-1 Like (GPD1L) Gene in Japanese Patients with Brugada Syndrome(Arrhythmia, diagnosis/Pathophysiology/EPS(07)(A),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese C
• OJ-009 A Common KCNE1 Polymorphism, D85N, is a Genetic Modifier of Long QT Syndrome(Arrhythmia, diagnosis/ Pathophysiology/ EPS(03)(A),Oral Presentation(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• OE-391 Cardiac sodium channel gene mutations are prevalent in Japanese patients with familial sick sinus syndrome(Arrhythmia, diagnosis/Pathophysiology/EPS(02)(A),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation So
• OE-276 Familial Dilated Cardiomyopathy with Conduction Disease Caused by Lamin A/C Mutations : Efficacy of the Cardiac Resynchronization Therapy with a Defibrillator(Cardiomyopathy, basic/clinical(01)(M),Oral Presentation(English),The 72nd Annual Scientif
• FRS-109 A novel SCN5A gain-of-function mutation M1875T associated with familial atrial fibrillation(New Horizon in Diagnosis and Pathophysiology of Arrhythmia(A),Featured Research Session,The 72nd Annual Scientific Meeting of the Japanese Circulation Soci
• A single mutation of cardiac sodium channel gene confers phenotypes of both Brugada and long QT syndromes
• Ion channel mutations and polymorphisms in Japanese patients with acquired long QT syndrome
• OJ-009 N- And C-terminal KCNE1 Mutations Cause Distinct Phenotypes of Long QT Syndrome(Arrhythmia, diagnosis/pathophysiology/EPS-03, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• PE-017 Moderate Hypothermia Causes Destabilization of Rotors without Wavelength Shortening in Favor of VT/VF Self-Termination(Arrhythmia, basic-4, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• OE-238 Mechanisms of Global and Regional Cooling-Assisted Defibrillation in a Bidomain Ventricular Model(Arrhythmia, basic-1 (A) OE40,Oral Presentation (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
• Role of Impaired Sympathetic Nerve Function in Enhancing Coronary Vasoconstriction in Patients with Hypertrophic Cardiomyopathy(Cardiomyopathy, Clinical 2 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• Endothelial Dysfunction May Play a Role in Left Ventricular Remodeling after Primary Coronary Angioplasty for Acute Myocardial Infarction(Acute Myocardial Infarction, Clinical (Pathophysiology) 4 (IHD), The 69th Annual Scientific Meeting of the Japanese C
• OE-094 Noninvasive Evaluation of Coronary Artery Plaque with ECG-Gated Multislice Computed Tomography(X-ray/CT/MRI/DSA 1 (I) : OE11)(Oral Presentation (English))
• IS092 Ion channel gene mutations in acquired long QT syndrome
• IS086 Novel missense mutation in the Pore region of HERG gene in Long QT syndrome Patient
• Prognostic Value of Normal Stress Myocardial Perfusion Imaging in Japanese Population : A Study Based on the J-ACCESS Study
• OJ-008 Variety of Clinical Phenotype in Patients with the LQT3 Syndrome due to a Hot Spot Mutation, E1784K, in SCN5A Gene(Arrhythmia, diagnosis/pathophysiology/EPS-03, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• OE-219 Role of Bradykinin and Chymase in Cardiorenal Function under Chronic ACE Inhibition in Heart Failure(OE37,Kidney/Renal Circulation/CKD 1 (H),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• PJ-306 ACE and Chymase Inhibition Prevents the Cardiac Remodeling Process Interacting with Cardiac Endothelin System in Heart Failure.(Heart failure, basic(06)(M),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Soci
• FRS-013 Chymase Inhibition Improves Cardiac Dysfunction through the Suppression of Excessive Oxidative Stress in Heart Failure(Cardiac Function "Ventricular Mechanics and Calcium Handling", The 71st Annual Scientific Meeting of the Japanese Circulation So
• Cardiac Mast Cell Chymase Plays a Significant Role in the Progression of Cardiac Remodeling via Collagen Accumulation(Inflammatory Heart Disease-Update and Future Perspective-, The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• 1 Brugada Syndrome and Diverse Phenotypes of Cardiac Sodium Channelopathies(Symposium 5 (SY-05) (A) New Findings of Mechanism and Therapeutic Strategies of Idiopathic Ventricular Fibrillation,Special Program,The 72nd Annual Scientific Meeting of the Japan
• PJ-046 Genotype-Phenotype Correlations of KCNJ2 Mutations in Japanese Patients with Andersen-Tawil Syndrome(Arrhythmia, diagnosis/pathophysiology/EPS-10, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• PJ-043 Clinical Characteristics for Japanese Patients with Genotyped Long-QT Syndrome(Arrhythmia, diagnosis/pathophysiology/EPS-10, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• Protective Mechanism of Adenosine to the Rat Arterial Endothelial Dysfunction Induced by Hydrogen Peroxide(Pharmacology)
• OE-362 Prognostic Value of Normal Stress Myocardial Perfusion Imaging in Japanese Population : a study Based on the J-ACCESS Study(Nuclear cardiology(01)(I),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• OE-121 Event ECG Recording is Useful Tool for Atrial Fibrillation (AF) Recurrence after Pulmonary Vein Isolation (PVI)(OE21,ECG/Body Surface Potential Mapping/Holter 2 (A),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circ
• PE-318 Early and Late Recurrences of Atrial Fibrillation after Pulmonary Vein Isolation : A Study Using Event-ECG Monitors(ECG/Body surface potential mapping/Holter(04)(A),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulat
• PE-141 Effects of Amiodarone and Bepridil, Multi-channel Blockers, on Spiral Wave Reentries in Human Atrial Model with Electrical and Structural Remodelings(Arrhythmia, therapy(07)(A),Poster Session(English),The 72nd Annual Scientific Meeting of the Japan
• OJ-007 Variable Genetic Backgrounds Between Congenital and Acquired Long-QT Syndromes(Arrhythmia, diagnosis/pathophysiology/EPS-03, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• Gender and Age Effects on Ventricular Repolarization Abnormality in Japanese General Carriers of a G643S Common Single Nucleotide Polymorphism for the KCNQ1 Gene(Clinical Investigation)
• PJ-613 Detailed Surface Electrocardiogram Characteristics Analysis of Repetitive Monomorphic Ventricular Tachycardia Derived from Left and Right Sinus of Valsalva(Arrhythmia, diagnosis/pathophysiology/EPS-14 (A) PJ103,Poster Session (Japanese),The 70th An
• OJ-342 The Prolongation of Transmural Dispersion of Ventricular Repolarization in Japanese Asymptomatic Carriers of G643S Single Nucleotide Polymorphism of KCNQ1 Gene(Genetics/Genetically engineered models/Gene therapy-1 (M) OJ57,Oral Presentation (Japane
• OE-158 Novel Anatomical Observations of the Left Atrium and the Pulmonary Vein by Multi-Detector Computed Tomography in Patients with Atrial Fibrillation(CT/DSA-1 (I) OE27,Oral Presentation (English),The 70th Anniversary Annual Scientific Meeting of the J
• Left Atrial Tachycardia Post Pulmonary Veins Isolation : Individual PV Isolation vs Combination of PV Isolation and Left Atrial Linear Ablation(Arrhythmia, Non-pharmacological Therapy 2 (A), The 69th Annual Scientific Meeting of the Japanese Circulation S
• Refractory Gradient is Responsible for the Increase in Ventricular Vulnerability Under Sodium Channel Blockade
• PJ-073 Ventricular Repolarization Abnormality in Japanese Carriers of G643S Single Nucleotide Polymorphism (SNP) of KCNQ1 Gene(Genetics/Genetically Engineered Models 1 (H) : PJ13)(Poster Session (Japanese))
• Multidetector-Row Computed Tomography Coronary Angiography : Optimization of Image Reconstruction Phase According to the Heart Rate
• Prognostic value of ECG-gated thallium-201 single-photon emission tomography in patients with coronary artery disease
• FRS-019 Plakophilin-2 Mutations are Common in Japanese Arrhythmogenic Right Ventricular Cardiomyopathy(New Insights into Basic Mechanism of Arrhythmia(A),Featured Research Session,The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• OE-081 Mechanistic Basis for the Pathogenesis of Long QT Syndrome Associated with a Common Splicing Mutation in KCNQ1 Gene(Arrhythmia, basic-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• FRS-078 Spectrum and Prevalence of Cardiac Sodium Channel (SCN5A) Mutations in a Cohort of 194 Unrelated Patients Referred for Inherited Arrhythmias(Arrhythmia (basic), The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• PJ-190 A KCNE1 Single Nucleotide Polymorphism, D85N, Serves as a Modifier in Forme-fruste Type of Long QT syndrome(Genetics/Genetically engineered models/Gene therapy-3 (M) PJ32,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of t
• OJ-349 High Incidence of Cardiac Events for Long-QT Syndrome with Compound Mutations(Arrhythmia, diagnosis/pathophysiology/EPS-4 (A) OJ59,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
• OJ-064 Age-Related Triggers for Life-Threatening Arrhythmia in Genotyped Long-QT Syndrome(Arrhythmia, diagnosis/pathophysiology/EPS-3 (A) OJ11,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
• Blockade of Angiotensin II Type 1 Receptor Improves the Arrhythmia Morbidity in Mice With Left Ventricular Hypertrophy
• Relationship between exercise capacity and cardiac diastolic function assessed by time-volume curve from 16-frame gated myocardial perfusion SPECT
• Electrophysiological characteristics of symptomatic and asymptomatic Brugada syndrome
• Successful Radiofrequency Current Catheter Ablation of Accessory Atrioventricular Pathway After Tricuspid Replacement in Ebstein's Anomaly
• Functional Compartmentalization of ATP is Involved in the Angiotensin II-mediated Closure of Cardiac ATP-sensitive K^+ Channels
• FRS-012 Clinical Characteristics and Acute Management for Electrical Storm of Torsade de Pointes in Genotyped Patients with Congenital Long QT Syndrome(Clinical Arrhythmia-2 (A) FRS3,Featured Research Session,The 70th Anniversary Annual Scientific Meeting
• Long-term effect of efonidipine therapy on plasma aldosterone and left ventricular mass index in patients with essential hypertension
• PJ-641 Comparison of Serum Levels of Cardiac Tropnin I and T in Patients with Chronic Heart Failure(PJ108,Heart Failure (Laboratory/Biomarkers) 1 (M),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• PJ-532 Angiotensin-Converting Enzyme Inhibition Increases Constitutive Release of Tissue Plasminogen Activator in Coronary Circulation(PJ090,Coronary Circulation/Chronic Coronary Disease (Basic/Clinical) (IHD),Poster Session (Japanese),The 73rd Annual Sci

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