Genetic Polymorphism of Enzymes Involved in Xenobiotic Metabolism and the Risk of Lung Cancer

スポンサーリンク

概要

• 論文の詳細を見る

• Chronic inhalation of cigarette smoke is a major risk factor for the development of lung cancer. It has been suggested that genetic susceptibility may contribute to the risk, because only a small portion of smokers develops the disease. Several polymorphisms that involve the metabolic activation or detoxification of carcinogens derived from cigarette smoke have been found to be associated with lung cancer risk. Many studies have focused on the relation between the distribution of polymorphic variants of different forms of the metabolic enzymes and lung cancer susceptibility. In this respect two groups of genetic polymorphisms of enzymes involved in xenobiotic metabolism, cytochrome P450 (CYP) and glutathione S-transferases (GSTs), have been discussed. CYP multigene superfamily consists of 10 subfamilies (CYP1-CYP10). A positive association between development of lung cancer and the mutant homozygous genotype of CYP1A1 gene has been reported in several Japanese populations but such an association has not been observed in either Caucasians or African-Americans. The relation between CYP2D6 and lung cancer remains conflicting and inconclusive. Several polymorphisms have been identified at the CYP2E1 locus. No definitive link between the polymorphisms of CYP2E1 and the risk of lung cancer has, however, been identified. The role of other CYP2 isoforms in lung carcinogenesis has not been sufficiently investigated. GSTs form a superfamily of genes consisting of five distinct families, named GSTA, GSTM, GSTP, GSTT and GSTS. The role of GSTM, GSTT1 or GSTP1 polymorphism in modifying the lung cancer risk may be more limited than has been so far anticipated. Although some genetic polymorphisms discussed here have not shown significant increases/decreases in risk, individuals with differing genotypes may have different susceptibilities to lung cancer. Hopefully, in future studies it will be possible to screen for lung cancer using specific biomarkers.

• 日本衛生学会の論文

著者

• Kiyohara Chikako

  Department Of Preventive Medicine Graduate School Of Medical Sciences Kyushu University

• Kiyohara Chikako

  Department Of Chemical Engineering Faculty Of Engineering Tokyo University Of Agriculture And Techno

• SHIRAKAWA Taro

  Dept. of Health Promotion and Human Behavior, Kyoto University Graduate School of Public Health

• SHIRAKAWA Taro

  Department of Health Promotion and Human Behavior, Kyoto University Graduate School of Public Health

• Hopkin Julian

  Experimental Medicine Unit University Of Wales

• Shirakawa Taro

  Dep. Of Health Promotion And Human Behavior Kyoto Univ. Graduate School Of Public Health

• Shirakawa Taro

  Department Of Health Promotion And Human Behavior Kyoto University

関連論文

• The Relationship between Aryl Hydrocarbon Hydroxylase and Polymorphisms of the CYP1A1 Gene
• Methicillin-Resistant Staphylococcus Aureus (MRSA) Isolation from pharyngeal Swab Cultures of Japanese Elderly at Admission to a Geriatric Hospital
• The correlation between GI-tract microbiota and allergy in Japanese infants by molecular analysis
• Molecular Monitoring of the Developmental Bacterial Community in the Gastrointestinal Tract of Japanese Infants
• Ethical Issues in Cancer Epidemiology and Disease Susceptibility Genes
• Gender Difference in Lung Cancer Susceptibility
• Association of the RIP2 Gene with Childhood Atopic Asthma
• Cu-Zn/Al_2O_3/Al-Plate Catalyst for a Methanol Reformer
• Genetic Influences on Smoking Behavior and Nicotine Dependence : a Review
• CYP2A13, CYP2A6, and the Risk of Lung Adenocarcinoma in a Japanese Population
• Novel Nonsynonymous Polymorphisms of the CYP1A1 Gene in Japanese
• An association study of asthma and related phenotypes with polymorphisms in negative regulator molecules of the TLR signaling pathway
• Relation of surgery, tumor site, and age group to the loss of reality testing in Japanese patients with malignant tumors : A study of a hospital-based sample with a consultation-liaison service
• Efficacy of day care treatment against readmission in patients with schizophrenia : A comparison between out-patients with and without day care treatment
• Environmental Factors and Aryl Hydrocarbon Hydroxylase Activity (CYP1A1 Phenotype) in Human Lymphocytes
• Genetic Polymorphism of Enzymes Involved in Xenobiotic Metabolism and the Risk of Colorectal Cancer
• The Case Fatality Rate of Methicillin-Resistant Staphylococcus aureus (MRSA) Infection among the Elderly in a Geriatric Hospital and Their Risk Factors
• Genetic Polymorphism of Enzymes Involved in Xenobiotic Metabolism and the Risk of Lung Cancer
• Genetic Susceptibility to Atopic Dermatitis
• Environmental Factors and Allergic Disorders
• Obesity, Weight Gain and Risk of Colon Adenomas in Japanese Men
• Development of a Monitoring System for Human Exposure to Tritium : Chromosome Aberrations in Human Lymphocytes Exposed to HTO
• Molecular epidemiology of major depressive disorder
• Suicidal risk factors and completed suicide : meta-analyses based on psychological autopsy studies
• Allergic disorders : A model for establishing how to prevent common disease
• Differences in Developing Intestinal Microbiota between Allergic and Non-Allergic Infants: A Pilot Study in Japan
• Differences in Developing Intestinal Microbiota between Allergic and Non-Allergic Infants : A Pilot Study in Japan
• Genetic and environmental factors of atopy

もっと見る 閉じる

スポンサーリンク