Gender Difference in Lung Cancer Susceptibility <Review>
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概要
- 論文の詳細を見る
Several epidemiological studies indicate that for a given number of cigarette smoked, females may be at higher risk of lung cancer compared with males. Females who smoke appear to be at higher risk of developing small cell lung cancer than squamous cell lung cancer, whereas men who smoke have a similar risk for the two histologic conditions.Molecular epidemiological studies have also indicated gender differences in the genetic and biochemical alterations in lung cancer. Higher levels of polycyclic aromatic hydrocarbon-DNA adducts were observed in female lung cancer patients compared with males, even though the level of tobacco carcinogens was lower among the females than among the males. A higher frequency of G to T transversion mutations in the p53 gene has been observed in females compared with males. Gender differences have been identified in the expression of cytochrome P4501 A1 gene or gastrin-releasing peptide receptor gene, with females exhibiting higher gene expression.Thus, the risk for lung cancer is consistently higher in females than in males at every level of exposure to cigarette smoking; odds ratios for an sociation of lung cancer with smoking are 1.4-fold to 1.9-fold higher for females than for males, depending on the histologic type of lung cancer.Whether lung cancer represents a different disease in women than in men is unclear. If the hypothesis regarding gender differences in genetic susceptibility to lung cancer proves to be true, education for reducing passive and active exposure to cigarette smoke must have a high priority for female's health.
- 札幌医科大学の論文
著者
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WASHIO Masakazu
Department of Public Health, Sapporo Medical University School of Medicine
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Kiyohara Chikako
九州大学 医学研究院予防医学分野
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Kiyohara Chikako
九州大学 農学研究院生物機能科学
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Kiyohara Chikako
和歌山県立医科大学 医学部衛生学教室
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Kiyohara Chikako
Department Of Preventive Medicine Graduate School Of Medical Sciences Kyushu University
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Kiyohara Chikako
Dep. Of Preventive Medicine Div. Of Social Medicine Graduate School Of Medical Sciences Kyushu Univ.
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KIYOHARA Chikako
Kyushu University Graduate School of Medical Sciences
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Kiyohara C
Kyushu Univ. Fukuoka Jpn
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WASHIO Masakazu
Research Institute for Science and Engineering, Waseda University
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YOSHIMASU Kouichi
Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University
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Kiyohara Chikako
Department Of Chemical Engineering Faculty Of Engineering Tokyo University Of Agriculture And Techno
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Kiyohara Chikako
Department Of Public Health Faculty Of Medicine Kyushu University
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Washio M
Department Of Public Health Sapporo Medical University School Of Medicine
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Washio M
Kyushu Univ.
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Washio Masakazu
Department Of Preventive Medicine Graduate School Of Medical Sciences Kyushu University
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WASHIO MASAKAZU
Imazu Red Cross Hospital
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Yoshimasu Kouichi
Department Of Hygiene School Of Medicine Wakayama Medical University
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Yoshimasu K
Kyushu Univ.
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WASHIO Masakazu
Department of Community Health and Clinical Epidemiology, St. Mary's College
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