Differences in Developing Intestinal Microbiota between Allergic and Non-Allergic Infants : A Pilot Study in Japan
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概要
- 論文の詳細を見る
A series of chemical analogs of sodium houttuynin, the major constituent in the volatile oil of the perennial plant Houttuynia cordata Thunb, were studied for in vitro inhibition of renin activity. At a reaction concentration of 0.196 mg/ml, each of the sodium houttuynin analogs (SHAs), viz., hexanoyl acetal sodium sulfite (SHA-C6), octanoyl acetal sodium sulfite (SHA-C8), decanoyl acetal sodium sulfite (SHA-C10), dodecanoyl acetal sodium sulfite (SHA-C12) and tetradecanoyl acetal sodium sulfite (SHA-C14), inhibited renin activity up to 34.37%, 44.03%, 79.33%, 83.04%, and 93.19% respectively. The IC50 values (the concentration of SHA that is required to reduce renin activity by 50%) of the most potent analogs were 273, 195, and 44 μM for SHA-C10, SHA-C12, and SHA-C14 respectively. Kinetic studies with SHA-14 indicated a linear mixed-type of enzyme inhibition with a Ki value of 45.35 μM. It was concluded that the SHAs constitute potentially useful ingredients for the formulation of antihypertensive products.
- 2007-09-23
著者
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Kiyohara Chikako
Department Of Chemical Engineering Faculty Of Engineering Tokyo University Of Agriculture And Techno
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Nakayama Jiro
Department Of Bioscience And Biotechnology Faculty Of Agriculture Graduate School Kyushu University
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Sonomoto Kenji
Department Of Biochemical Engineering And Science Faculty Of Computer Science And Systems Engineerin
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Nakayama Jiro
Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni
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Shirakawa Taro
Department Of Health Promotion And Human Behavior Kyoto University Graduate School Of Public Health
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Shirakawa Taro
Department Of Health Promotion And Human Behavior Kyoto University
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Tsubouchi Mina
Department Of Bioresources Science Faculty Of Agriculture Kochi University
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Tsubouchi Mina
Department Of Health Promotion And Human Behavior Kyoto University Graduate School Of Public Health
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Tanaka Shigemitsu
Department Of Bioscience And Biotechnology Faculty Of Agriculture Graduate School Kyushu University
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Kiyohara Chikako
Department Of Preventive Medicine Division Of Social Medicine Graduate School Of Medical Sciences Ky
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Songjinda Prapa
Department Of Bioscience And Biotechnology Faculty Of Agriculture Graduate School Kyushu University
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Aluko Rotimi
Department Of Food Science University Of Guelph
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Tateyama Atsushi
Department Of Bioscience And Biotechnology Faculty Of Agriculture Graduate School Kyushu University
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Yuan Lujiang
Department Of Human Nutritional Sciences University Of Manitoba
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Wu Jianping
Department Of Agricultural Food And Nutritional Science University Of Alberta
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