Induction of Anti-inflammatory Responses by Dietary Momordica charantia L. (Bitter Gourd)(Food & Nutrition Sience)
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概要
- 論文の詳細を見る
We assessed the immunomodulatory activity of Momordica charantia L. (bitter gourd), a vegetable that has been reported to possess various bioactivities. We examined the effect of bitter gourd on intestinal immunity by monitoring the TGF-β and IL-7 secretion from Caco-2 cells and the IL-10 and IL-12 secretion from THP-1 cells that are used as in vitro models of the intestinal epithelium and monocyte/macrophages, respectively. We also determined the in vivo immunological responses of rats fed on bitter gourd for 3 weeks. We found that bitter gourd induced a decrease in the intestinal secretion of IL-7 and an increase in the secretions of TGF-β and IL-10, these effects reflecting the bitter gourd-induced changes in systemic immunity, i. e., a decrease in the number of lymphocytes, increases in the populations of Th cells and NK cells, and increase in the Ig production of lymphocytes. Dietary bitter gourd may therefore induce both intestinal and also systemic anti-inflammatory responses.
- 社団法人日本農芸化学会の論文
- 2003-12-23
著者
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Manabe Mariko
Department Of Food Science And Nutrition Faculty Of Human Life And Science Doshisha Women's Col
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Nakasa T
Department Of Food Science And Nutrition Faculty Of Human Life And Science Doshisha Women's Col
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Nakasa Teruko
Department Of Nutrition Doshisha Women's College
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Okinaka O
Department Of Food Science And Nutrition Faculty Of Human Life And Science Doshisha Women's Col
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Okinaka Osamu
Department Of Nutrition Doshisha Women's College
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TAKENAKA Ryo
Department of Food Science and Nutrition, Faculty of Human Life and Science, Doshisha Women's Colleg
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Takenaka Ryo
Department Of Food Science And Nutrition Faculty Of Human Life And Science Doshisha Women's Col
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OKINAKA Osamu
Department of Food Science and Nutrition, Faculty of Human Life and Science, Doshisha Women's College of Liberal Arts
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Nakasa Teruko
Department of Food Science and Nutrition, Faculty of Human Life and Science, Doshisha Women's College of Liberal Arts
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- Induction of Anti-inflammatory Responses by Dietary Momordica charantia L. (Bitter Gourd)(Food & Nutrition Sience)