Regulation of Virulence Factors of Enterohemorrhagic Escherichia coli O157 : H7 by Self-Produced Extracellular Factors
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概要
- 論文の詳細を見る
Enterohemorrhagic Escherichia coli (EHEC) O157 : H7 causes serious diarrhea and hemolytic uremic syndrome in humans. The expressions of EspD and intimin by O157 : H7 have now been shown to be downregulated by medium conditioned by O157 : H7 grown at stationary phase. Preparation of conditioned medium showing the effect on the amount of EspD was not dependent on temperature or growth medium, but was dependent on growth phase. Inhibition of EspD and intimin expression was also induced by medium conditioned by E. coli K-12 strains and homoserine lactone, a signal molecule of the quorum-sensing system in Gram-negative bacteria. These results suggest the possibility that the quorum-sensing system mediated by self-produced extracellular factors plays an important role in control of colonization of EHEC O157 : H7.
- 社団法人日本農芸化学会の論文
- 2000-11-23
著者
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TATSUNO Ichiro
Department of Clinical Cell Biology (Second Department of Medicine), Chiba University Graduate Schoo
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TOBE Toru
Department of Bacterial Infection, Institute of Medical Science, The University of Tokyo
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SASAKAWA Chihiro
Department of Bacterial Infection, Institute of Medical Science, The University of Tokyo
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Tobe Toru
Department Of Microbiology And Immunology Institute Of Medical Science University Of Tokyo
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Tobe Toru
Department Of Bacterial Infection Institute Of Medical Science The University Of Tokyo
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Kanamaru Kyoko
Laboratory Of Molecular Genetics Department Of Molecular Biology Institute Of Molecular And Cellular
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Tatsuno I
Department Of Microbiology And Immunology Institute Of Medical Science University Of Tokyo
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Tatsuno Ichiro
Department Of Bacteriology Institute Of Medical Science The University Of Tokyo
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KANAMARU Kyoko
Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo
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KANAMARU Kengo
Institute of Molecular and Cellular Biosciences, University of Tokyo
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Kanamaru Kyoko
Department Of Microbiology And Immunology Institute Of Medical Science University Of Tokyo:(present
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Sasakawa C
Univ. Tokyo Tokyo Jpn
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Sasakawa Chihiro
Department Of Bacterial Infection Institute Of Medical Science The University Of Tokyo
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Kanamura Kyoko
Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo:(Present address)The Agricultural High-Tech Research Center, Meijo University
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Kanamura Kengo
Institute of Molecular and Cellular Biosciences, University of Tokyo
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