Synthesis of Amino Acid Derivatives of Kojic Acid and Their Tyrosinase Inhibitory Activity

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概要

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• Six N-carbobenzozy amino acid derivatives of kojic acid were synthesized to improve the tyrosinase inhibitory activity of kojic acid. All derivatives showed stronger activities than kojic acid. Among them, the L-phenylalanine derivative was the strongest inhibitor and its IC_<50> value was about 1/80 that for kojic acid. Theinhibition mechanism of these derivatives is considered to be a noncompetitive one similar to that of kojic acid.

• 社団法人日本農芸化学会の論文
• 1995-09-23

著者

• Tadasa Koji

  Department Of Bioscience And Biotechnology Faculty Of Agriculture Shinshu University

• TANAKA Hiroshi

  Laboratory of Environmental biology, Graduate school of Science and Technology, Yamaguchi University

• NAKAMURA Toshiko

  Department of Physics, College of General Education, Osaka University

• Kayahara Hiroshi

  Department Of Bioscience And Biotechnology Faculty Of Agriculture Shinshu University

• Kobayashi Yoshikane

  The United Graduate School of Agricultural Science, Gfu University

• Kobayashi Yoshikane

  The United Graduate School Of Agricultural Science Gfu University

• Nakamura Toshiko

  Department Of Bioscience And Biotechnology Faculty Of Agriculture Shinshu University

• KAYAHARA Hiroshi

  Department of Agricultural Chemistry, Faculty of Agriculture, Shinshu University

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