Studies on Glycosidase Inhibitors : Synthesis of 2,6-Dideoxy-2,6-imino-L-gulonic Acid and Its 3-Deoxy Analog
スポンサーリンク
概要
- 論文の詳細を見る
2,6-Dideoxy-2,6-imino-L-gulonic acid (1) with inhibitory activity against β-D-glucuronidase and α-L-iduronidase was stereoselectively synthesized from 2,3-di-O-benzyl-N-benzyloxycarbonyl-6-O-t-butyldiphenylsilyl-1,5-dideoxy-1,5-imino-D-glucitol (4). Through a deoxygenation reaction at the C-4 position of the latter, 2,3,6-trideoxy-2,6-imino-L-gulonic acid (2) was also prepared.
- 社団法人日本農芸化学会の論文
- 1995-04-23
著者
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KUZUHARA Hiroyoshi
Department of Functional Materials Science, Faculty of Engineering, Saitama University
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TAKAHASHI Shunya
The Institute of Physical and Chemical Research (RIKEN)
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Takahashi Shunya
The Institute Of Physical And Chemical Research (rlken)
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Kuzuhara Hiroyoshi
Department Of Functional Materials Science Faculty Of Engineering Saitama University
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Kuzuhara Hiroyoshi
Department Of Engineering Saitama University
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- Studies on Glycosidase Inhibitors : Synthesis of 2,6-Dideoxy-2,6-imino-L-gulonic Acid and Its 3-Deoxy Analog