Pseurotin A and 8-O-Demethylpseurotin A from Aspergillus fumigatus and Their Inhibitory Activities on Chitin Synthase
スポンサーリンク
概要
- 論文の詳細を見る
Two inhibitors of chitin synthase were isolated from submerged cultures of an osmophilic Aspergillus fumigatus strain and identified as pseurotin A (1) and its 8-O-demethyl derivative (2). The two compounds inhibited both the solubilized and the membrane-bound forms of the enzyme, but do not have antifungal or antibacterial activities. The IC_<50> of pseurotin A was 81 μM for the solubilized enzyme. 8-O-Demethylpseurotin was less active with an IC_<50> of 192 μM. The structures of the compounds were elucidated by spectroscopical methods.
- 社団法人日本農芸化学会の論文
- 1993-06-23
著者
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Sterner Olov
Department Of Organic And Bioorganic Chemistry
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Anke H
Institute Of Biotechnology And Drug Research(ibwf)
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Anke Heidrun
Department Of Biotechnology University Of Kaiserslautern
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Wenke Jorg
Department of Biotechnology, University of Kaiserslautern
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Wenke Jorg
Department Of Biotechnology University Of Kaiserslautern
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