Inhibition of Solubilized Chitin Synthase by Chlorinated Aromatic Compounds Isolated from Mushroom Cultures(Biological Chemistry)

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概要

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• 3,5-Dichloro-4-methoxybenzyl alcohol, a novel natural metabolite, was isolated from submerged cultures of a Stropharia species due to its inhibitory activity towards chitin synthase. In the same screening, drosophilin A and other chlorinated aromatic compounds were detected. Comparison of the activity of the natural metabolites with that of synthetic analogues showed the necessity of the chlorine substituents for the enzyme inhibition. Hexachlorophene strongly inhibited solubilized chitin synthase with an apparent Ki of 8.5 μM. The inhibition could be reversed by the addition of lecithin.

• 社団法人日本農芸化学会の論文
• 1990-06-23

著者

• Steglich Wolfgang

  Department Of Chemistry University Of Bonn

• Anke Heidrun

  Department Of Biotechnology University Of Kaiserslautern

• PFEFFERLE Walter

  Department of Biotechnology, University of Kaiserslautern

• BROSS Monika

  Department of Chemistry, University of Bonn

• Bross Monika

  Department Of Chemistry University Of Bonn

• Pfefferle Walter

  Department Of Biotechnology University Of Kaiserslautern

関連論文

• Pseurotin A and 8-O-Demethylpseurotin A from Aspergillus fumigatus and Their Inhibitory Activities on Chitin Synthase
• Inhibition of Solubilized Chitin Synthase by Chlorinated Aromatic Compounds Isolated from Mushroom Cultures(Biological Chemistry)
• PD37 THE TRANSFORMATION OF THE ANTIFUNGAL SESQUITERPENE ISOVELLERAL BY THE PARASITIC FUNGUS CALCARISPORIUM ARBUSCULA

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