Osteopontin is Released From the Heart Into the Coronary Circulation in Patients With a Previous Anterior Wall Myocardial Infarction
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概要
- 論文の詳細を見る
The present study was designed to clarify whether osteopontin, an extracellular matrix protein, is released from the heart into the coronary circulation in patients with a previous (>3 months) anterior wall myocardial infarction (MI). Using a commercially available enzyme immunoassay kit, plasma concentrations of osteopontin were measured in 30 patients (26 men, 4 women; mean age, 61±12 years). Blood samples were obtained from the aortic root and coronary sinus. The difference in the plasma concentrations of osteopontin in the aortic root and coronary sinus, which reflects the cardiac production of osteopontin released into the coronary circulation, was compared with the left ventricular ejection fraction (LVEF) and volumes obtained from contrast left ventriculog- raphy. Plasma osteopontin concentrations were significantly higher in the coronary sinus than in the aortic root (672±446 vs 610±398ng/ml, p=0.02). The transcardiac gradient of plasma osteopontin concentration correlated negatively with LVEF (r=-0.55, p=0.0005) and positively with left ventricular (LV) end-diastolic (r=0.63, p= 0.0001) and end-systolic volume indexes (r=0.79, p<0.0001). This is the first study to show that in patients with a previous anterior wall MI osteopontin is released from the heart into the coronary circulation in proportion to the LV systolic function and volumes, suggesting that this extramatrix protein is associated with post-MI LV remodeling. (Circ J 2003; 67: 742-744)
- 社団法人日本循環器学会の論文
- 2003-08-20
著者
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Tamura Akira
Internal Medicine 2 Faculty Of Medicine Oita University
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NASU Masaru
Second Depertment of Internal Medicine, Oita Medical University.
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Tamura Akira
Second Department of Internal Medicine, Oita University
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Aso Nobuko
Division Of Cardiovascular Medicine Oita Nakamura Hospital
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Nasu Masaru
Second Department Of Internal Medicine Oita University
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Nasu Masaru
Second Department Of Internal Medicine Department Of Infectious Diseases Faculty Of Medicine Oita Un
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Aso Nobuko
Second Department of Internal Medicine, Oita University
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Aso Nobuko
Second Department Of Internal Medicine Oita University
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Hazuku Takayuki
Second Department of Internal Medicine, Oita Medical University
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Shingai Maki
Second Department of Internal Medicine, Oita Medical University
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Shingai Maki
Second Department Of Internal Medicine Oita Medical University
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Nasu Masaru
The Second Department Of Internal Medicine Oita Medical University
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Hazuku Takayuki
Second Department Of Internal Medicine Oita Medical University
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Tamura Akira
Second Department Of Internal Medicine Oita Medical University
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Aso Nobuko
Second Department Of Internal Medicine Oita Univeristy
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Tamura Akira
Second Department Of Internal Medicine Faculty Of Medicine Oita University
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