Effects of Atorvastatin and Pravastatin on Malondialdehyde-Modified LDL in Hypercholesterolemic Patients
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概要
- 論文の詳細を見る
The aim of the present study was to compare the effects of atorvastatin and pravastatin on lipid parameters and the concentration of malondialdehyde-modified low-density lipoprotein (MDA-LDL) in hypercholesterolemic patients. A total of 17 patients (10 men, 7 women ; mean age, 68±9 years) who were indicated for drug therapy based on the National Cholesterol Education Program II underwent an 8-week regimen of atorvastatin (10mg/day) or pravastatin (10mg/day) with a 4-week washout period between drugs. After an overnight fast, lipid parameters and MDA-LDL concentration were measured before and after the 8-week treatment with each drug. Both atorvastatin and pravastatin produced significant reductions in low-density lipoprotein (LDL) cholesterol and MDA-LDL concentrations, with a significant increase in high-density lipoprotein cholesterol concentration. The percent reductions in LDL cholesterol and MDA-LDL concentration were significantly greater with atorvastatin than pravastatin (46±6% vs 24±10%, p<0.0001, and 44±10% vs 14±13%, p<0.0001, respectively). The ratios of percent reductions in MDA-LDL concentrations and percent reductions in LDL cholesterol concentrations were significantly greater for atorvastatin than pravastatin (0.96±0.19 vs 0.59±0.55, p<0.0001). In conclusion, atorvastatin reduced serum concentrations of LDL cholesterol and MDA-LDL to a greater degree than pravastatin, indicating that atorvastatin not only has stronger lipid-lowering effects, but also stronger antioxidative effects than pravastatin.
- 社団法人日本循環器学会の論文
- 2003-09-20
著者
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Watanabe Toru
Division Of Cardiovascular Medicine Oita Nakamura Hospital
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Tamura Akira
Internal Medicine 2 Oita University
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NASU Masaru
Second Depertment of Internal Medicine, Oita Medical University.
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Tamura Akira
Second Department of Internal Medicine, Oita University
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Watanabe Toru
Second Department of Internal Medicine, Oita University
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Nasu Masaru
Second Department Of Internal Medicine Oita University
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Nasu Masaru
Second Department Of Internal Medicine Department Of Infectious Diseases Faculty Of Medicine Oita Un
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Nasu Masaru
The Second Department Of Internal Medicine Oita Medical University
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Tamura Akira
Second Department Of Internal Medicine Oita Medical University
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Watanabe Toru
Second Department Of Internal Medicine
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Tamura Akira
Second Department Of Internal Medicine Faculty Of Medicine Oita University
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