Relationship Between Plasma Oxidized Low-Density Lipoprotein and the Coronary Vasomotor Response to Acetylcholine in Patients With Coronary Artery Disease

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概要

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• The present study examined the relation of plasma oxidized low-density lipoprotein (LDL) levels to plasma LDL cholesterol levels and the impairment of endothelium-dependent coronary vasorelaxation in patients with coronary artery disease (CAD). In the first study, the relationship between plasma levels of oxidized LDL and LDL cholesterol were investigated in 88 patients with CAD. In the second study, the changes in the diameter of the left anterior descending (LAD) and the left circumflex (LCX) coronary arteries were measured after intracoronary administration of acetylcholine (15μg) and isosorbide dinitrate (2.5 mg) in 15 patients with CAD. Plasma oxidized LDL levels were determined with a sandwich enzyme-linked immunosorbent assay. Plasma oxidized assay LDL levels did not correlate with plasma LDL cholesterol levels (r=-0.03, p=NS). The % diameter changes (mean±SEM) in the LAD and LCX after intracoronary acetylcholine were -8.3±3.5% and -10±4.2%, respectively. The % diameter changes in the LAD and LCX after intracoronary isosorbide dinitrate were 23±4.8 % and 23±5.1 %, respectively. The % diameter changes in the LAD and LCX inversely correlated with plasma oxidized LDL levels after intracoronary acetylcholine (LAD: r=-0.55, p=0.03; LCX: r=-0.59, p=0.02), but were not after intracoronary isosorbide dinitrate. Plasma LDL cholesterol, triglyceride, and high-density lipoprotein cholesterol levels did not correlate with the coronary vasoreaction to acetylcholine. In conclusion, plasma oxidized LDL levels do not correlate with plasma LDL-cholesterol levels and are related to impairment of endothelium-dependent coronary vasodilation in patients with CAD.

• 社団法人日本循環器学会の論文
• 2000-10-20

著者

• Watanabe Toru

  Division Of Cardiovascular Medicine Oita Nakamura Hospital

• NASU Masaru

  Second Depertment of Internal Medicine, Oita Medical University.

• Tamura Akira

  Second Department of Internal Medicine, Oita University

• Watanabe Toru

  Second Department of Internal Medicine, Oita University

• Nasu Masaru

  Second Department Of Internal Medicine Oita University

• Nasu Masaru

  Second Department Of Internal Medicine Department Of Infectious Diseases Faculty Of Medicine Oita Un

• Nakaishi Toru

  Second Department of Internal Medicine, Faculty of Medicine, Oita University

• Nakaishi Toru

  Second Department Of Internal Medicine Faculty Of Medicine Oita University

• Mikuriya Yoshiaki

  Second Department of Internal Medicine, Oita Medical University

• Nasu Masaru

  The Second Department Of Internal Medicine Oita Medical University

• Mikuriya Yoshiaki

  Second Department Of Internal Medicine Oita Medical University

• Tamura Akira

  Second Department Of Internal Medicine Oita Medical University

• Watanabe Toru

  Second Department Of Internal Medicine Faculty Of Medicine Oita University

• Watanabe Toru

  Second Department Of Internal Medicine

• Tamura Akira

  Second Department Of Internal Medicine Faculty Of Medicine Oita University

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