短時間の高強度間欠的運動は尿中8-OHdG含有量を増加させる

概要

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The purpose of this study was to examine whether urinary 8-hydroxydeoxyguanosine (8-OHdG) content, which was assumed to be a biomarker of oxidative DNA damage, increased after short-term and high-intensity intermittent exercise. Fourteen healthy males (age ; 19.9±0.8 yr, height ; 173.7±6.1cm, weight ; 69.2±11.0 kg) performed an intermittent sprint cycling exercise for 20-set. Exercise consisted of 7-sec maximal pedaling (body weight ×0.08 kp) and 53-sec recovery (49-sec unloaded cycling with 4-sec setting for an ergometer). Mean heart rate during exercise was 156.0±2.9 bpm (n=13). Urine samples were collected just before (Pre) and 1 hour after exercise (Post). Enzyme-linked immunosorbent assay (ELISA) was used for analyzing urinary 8-OHdG content. Urinary 8-OHdG content increased after exercise in all subjects. There was significant difference between Pre (8.38±1.58 ng・ml^<-1>) and Post (26.84±3.17 ng・ml^<-1>) values (p<0.001). It is likely that superoxide anion production increased due to activated aerobic energy metabolism and ischemia-reperfusion in working muscles. We conclude that urinary 8-OHdG content increases after short-term and high-intensity intermittent exercise.
日本運動生理学会の論文
2004-10-30