ABNORMAL POLYAMINE METABOLISM IN HYPERTENSIVE CARDIAC HYPERTROPHY
スポンサーリンク
概要
- 論文の詳細を見る
In order to assess myocardial hypertrophic activity during the process of hypertensive cardiac hypertrophy in the presence and absence of treatment with anti-hypertensive agents, we analyzed myocardial polyamine concentrations in spontaneous hypertensive (SHR) rats and control rats of Wistar Kyoto (WKY) strain. The anti-hypertensive agents studied were diltiazem, hydralazine and captopril, each of which was administered for 5 weeks. In comparison with WKY rats, SHR rats showed elevated blood pressure and enlarged hearts with higher myocardial spermidine concentration. Although blood pressure was lowered in the diltiazem-treated SHR rats, heart weight and myocardial spermidine concentration increased as in untreated SHR rats. In the hydralazine-treated group increases in both blood pressure and myocardial spermidine concentration were all suppressed. Since spermidine level appears to be a sensitive indicator of hypertrophic activity in the heart, this study suggests that captopril exerts an inhibitory effect on hypertensive cardiac hypertrophy whereas diltiazem does not. It also suggests that hypertrophy may reach a certain plateau level earlier in the hydralazine-treated animals than in others.
- 社団法人日本循環器学会の論文
- 1988-10-20
著者
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Aihara Kazuo
Division Of Clinical Pharmacology And Therapeutics Department Of Internal Medicine Jikei University
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Ogawa Kazuo
Jikei University School of Medicine
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Isogai Yukihide
Department of Internal Medicine(III), Jikei University School of Medicine
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ISOGAI Yukihide
The Third Department of Internal Medicine, Jikei University School of Medicine
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HAYASHI Shin-Ichi
Department of Immunology, School of Life Science Tottori University
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Ogawa Kazuhiko
Division Of Cardiology Department Of Internal Medicine The Jikei University School Of Medicine
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Mizokami Tsuneo
The Third Department of Internal Medicine, The Jikei University School of Medicine
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Shimizu Mitsuyuki
The Third Department of Internal Medicine, The Jikei University School of Medicine
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Ogawa Kazuhiko
The Third Department of Internal Medicine, The Jikei University School of Medicine
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Nakano Tomoko
The Third Department of Internal Medicine, The Jikei University School of Medicine
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Aihara Kazuo
The Third Department of Internal Medicine, The Jikei University School of Medicine
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Taniguchi Ikuo
The Third Department of Internal Medicine, The Jikei University School of Medicine
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MASUDA IZURU
The Third Department of Internal Medicine, The Jikei University School of Medicine
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IRIMAJIRI OSAMU
The Third Department of Internal Medicine, The Jikei University School of Medicine
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OZASA HARUKI
The Third Department of Internal Medicine, The Jikei University School of Medicine
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KAGEYAMA SHIGERU
The Third Department of Internal Medicine, The Jikei University School of Medicine
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Isogai Yukihide
Department Of Internal Medicine(iii) Jikei University School Of Medicine
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Isogai Yukihide
Third Department Of Internal Medicine The Jikei University School Of Medicine
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Isogai Yukihide
The Third Department Of Internal Medicine The Jikei University School Of Medicine
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Isogai Yukihide
The Third Department Of Internal Medicine Jikei University School Of Medicine
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Kageyama Shigeru
Division Of Clinical Pharmacology And Terapeutics Department Of Internal Medicine Jikei University S
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Shimizu Mitsuyuki
Division Of Cardiology Department Of Internal Medicine Jikei University School Of Medicine
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Masuda Izuru
The Third Department Of Internal Medicine The Jikei University School Of Medicine
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Hayashi Shin-ichi
Department Of Nutrition The Jikei University School Of Medicine
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Nakano Tomoko
He 3rd Department Internal Medicine; The Jikei University School Of Medicine
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Ozasa Haruki
The Third Department Of Internal Medicine The Jikei University School Of Medicine
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Taniguchi Ikuo
Division Of Cardiology Department Of Internal Medicine The Jikei University School Of Medicine
-
Irimajiri Osamu
he 3rd Department Internal Medicine; The Jikei University School of Medicine
-
Isogai Yukihide
Third Department Of Internal Medicine Jikei University School Of Medicine
-
Mizokami Tsuneo
The Third Department Of Internal Medicine The Jikei University School Of Medicine
-
Ogawa Kazuhiko
Jikei University School Of Medicine
-
Hayashi Shin-ichi
Department Of Immunology School Of Life Science Tottori University
-
Taniguchi Ikuo
The Third Department Of Internal Medicine The Jikei University School Of Medicine
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Shimizu Mitsuyuki
Division Of Cardiology Department Of Internal Medicine The Jikei University School Of Medicine Kashi
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Ogawa Kazuhiko
Division Of Cardiology Department Of Inernal Medicine The Jikei University School Of Medicine
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Hayashi Shin-ichi
Department of Nutrition, The Jikei University School of Medicine
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SHIMIZU Mitsuyuki
the Third Department of Internal Medicine, Jikei University School of Medicine
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