Effect of Amlodipine on Vascular Responses After Coronary Stenting Compared With an Angiotensin-Converting Enzyme Inhibitor

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Background Prevention of restenosis after coronary stenting is clinically important. We compared amlodipine and quinapril to determine which is more effective in preventing restenosis after stenting. Methods and Results Immediately after successful coronary stenting of 101 lesions in 63 consecutive patients, the patients were randomly divided into 2 groups : 32 patients with 48 lesions were administered amlodipine 5mg/day (group A), and 31 patients with 53 lesions were administered quinapril 10mg/day (group Q). Lesions were assessed by quantitative coronary angiography (QCA) before and immediately after stenting and in the follow-up phase. Intravascular ultrasound (IVUS) could only be performed on 20 lesions in group A and 16 lesions in group Q throughout the follow-up period. We analyzed each lesion at 5 sites. In the follow-up phase, the minimal lumen diameter in group A was significantly larger than that in group Q (1.88±0.64mm vs 1.52±0.53mm, p<0.01). In the follow-up phase, the neointimal area (stent area-lumen area) in group A was significantly smaller than that in group Q (1.9±0.5mm^2 vs 2.7±0.8mm^2 at the middle portion of stent, p<0.01). Conclusion These QCA and IVUS findings suggest that amlodipine has beneficial effects in inhibiting neointimal hyperplasia in stented lesions compared with quinapril.
2004-03-20